Eligibility criteria
Condition
Endometrial Neoplasms
Sex
Female
Age
18 + years
Inclusion criteria
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- Recurrent endometrial carcinoma
- Disease progression following one or two lines of prior treatment with platinum
containing chemotherapy
- Tumor tissue available at time of screening for PI3K analysis
- Adequate performance status
- Adequate glucose control, bone marrow, kidney, liver, and heart function
Exclusion criteria
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- More than 2 prior cytotoxic chemo regimens for endometrial carcinoma
- Prior therapy with an agent known to be a PI3K, and or mTOR and or AKT inhibitor
- Active brain metastases