- Male or female older than 50 years of age
- Eligibility must be determined by medical history, physical exam and clinical judgment
- Able to complete an electronic diary
- Available for duration of study
- Negative pregnancy test for subjects in group 2 age 50 to 64 years
- Practice abstinence or use reliable birth control if age is 50 to 64 years
- History of allergic reaction to any vaccine
- Previous vaccination with licensed or experimental pneumococcal vaccine
- S. pneumonia infection within past 5 years before investigational product
administration
- Known or suspected immunodeficiency or received treatment including cytotoxic agents
or systemic corticosteroids, serious chronic disorder such as malignancy cancer
- Receipt of plasma products or immunoglobulins within 60 days
- Bleeding conditions or diathesis
- Receipt of investigational product within 28 days before study entry
- Other severe acute or chronic medical or psychiatric condition