Ceftaroline China Pharmacokinetics Study

• Drug: Ceftaroline
  
  60-minute single intravenous dose of 600 mg of Ceftaroline on Days 1 and 8; 60-minute intravenous dose of 600 mg of Ceftaroline twice per day on Days 3-7.
• Drug: Ceftaroline
  
  Single intravenous dose on Days 1 and 9. Intravenous three times per day on Days 2-8.

• Experimental: Ceftaroline q12h
  
  Ceftaroline 600mg q12h
  Intervention: Drug: Ceftaroline
• Experimental: Ceftaroline q8h
  
  ceftaroline 600mg q8h
  Intervention: Drug: Ceftaroline

Inclusion Criteria:

• Provision of informed consent prior to any study specific procedures.
• Are healthy male or female Chinese volunteers aged between 18 and 45 inclusive.
• Have a Body Mass Index (BMI) between (and including) 19 and 24 kg/m2 and weigh at least 50 kg.
• Be willing to communicate with the investigator and comply with all study procedures.

Exclusion Criteria:

• Creatine clearance <80 mL/min as calculated by the Cockcroft Gault equation
• History of any hypersensitivity or allergic reaction to any ?-lactam antimicrobial.
• Symptoms of any clinically significant illness within 2 weeks of screening.
• Use of any other investigational compound or participation in another clinical trial within 2 months prior to Visit 2.
• Blood donation with 3 months of screening.