CP-751,871 Treatment For Patients With Multiple Myeloma

Back to Search
Print
Bookmark Trial

NCT01536145

Last updated date
Back to Search
Print
Bookmark Trial
FOR MORE INFORMATION
Study Location
Pfizer Investigational Site
Phoenix, Arizona, 85054, United States
See other locations
Contact
1-800-718-1021
[email protected]
Related Links

FOR MORE INFORMATION

Contact a representative by phone, email, or visiting the study website. Please see the references below:

By phone

Pfizer Clinical Trials Contact Center

1-800-718-1021

By email

Contact

[email protected]

Call Now

Eligibility Criteria
condition
The disease, disorder, syndrome, illness, or injury that is being studied.
Multiple Myeloma
Sex
Females and Males
Age
Pediatric Trials: 0-17 Years
Adult Trials: 18+ Years
18 + years
Inclusion Criteria
The factors, or reasons, that allow a person to participate in a clinical study.
Show details

- Previously treated multiple myeloma with a quantifiable serum (M spike ≥ 1 g/dL) and/or urine (≥ 200 mg/24-hr) paraprotein

- Adequate bone marrow, renal, liver and cardiac function

- Eastern Cooperative Oncology Group [ECOG] performance status less than or equal to 2

Exclusion Criteria
The factors, or reasons, that prevent a person from participating in a clinical study.
Show details


- Prior allogeneic stem cell transplant (alloSCT)


- Myelosuppressive chemotherapy or immunotherapy within 3 weeks prior to treatment with
CP-751,871


- Prior organ allograft


- Concurrent use of insulin, oral hypoglycemic medication, growth hormone (GH), or
growth hormone inhibitors


- Female patients who are pregnant or lactating

NEED INFO?

Questions about a trial? Call or email to reach a Pfizer Clinical Trial Contact Center Representative

Pfizer Clinical Trials Contact Center

1-800-718-1021

[email protected]

Call Now

TRY A NEW SEARCH

Search for Clinical Trials by condition, keyword or trial number. Share your location or enter your city or zip code to find studies near you.

Advanced Search

Based on your search, you may also be interested in

Multiple MyelomaStudy of the Safety and Efficacy of an Investigational Drug in Adult Patients With Multiple Myeloma
NCT00036140
  1. Los Angeles, California
  2. Los Angeles, California
  3. Rancho Mirage, California
  4. Cleveland, Ohio
  5. Marshfield, Wisconsin
ALL GENDERS
18 Years+
years
MULTIPLE SITES
Multiple MyelomaCP-751,871 Treatment For Patients With Multiple Myeloma
NCT01536145
  1. Phoenix, Arizona
  2. Scottsdale, Arizona
  3. Tampa, Florida
  4. Boston, Massachusetts
  5. Rochester, Minnesota
  6. New York, New York
ALL GENDERS
18 Years+
years
MULTIPLE SITES
Multiple MyelomaAn Investigational Drug, Palbociclib (PD-0332991), Is Being Studied In Combination With Velcade And Dexamethasone In Patients With Multiple Myeloma. Patients Must Have Received Prior Treatment For Multiple Myeloma.
NCT00555906
  1. Chicago, Illinois
  2. Chicago, Illinois
  3. Kansas City, Kansas
  4. Westwood, Kansas
  5. Baltimore, Maryland
  6. Detroit, Michigan
  7. St. Louis, Missouri
  8. St. Louis, Missouri
  9. St. Louis, Missouri
  10. Omaha, Nebraska
  11. Buffalo, New York
  12. New York, New York
  13. Philadelphia, Pennsylvania
  14. Pittsburgh, Pennsylvania
  15. Charleston, South Carolina
  16. Charleston, South Carolina
  17. Praha 2,
  18. Heidelberg,
  19. Mainz,
ALL GENDERS
18 Years+
years
MULTIPLE SITES
Multiple MyelomaPhase I study of Relapsed / Refractory Multiple Myeloma
NCT03269136
  1. Encinitas, California
  2. La Jolla, California
  3. La Jolla, California
  4. La Jolla, California
  5. San Diego, California
  6. Vista, California
  7. New York, New York
  8. Durham, North Carolina
  9. Nashville, Tennessee
  10. Nashville, Tennessee
  11. Calgary, Alberta
  12. Calgary, Alberta
  13. Edmonton, Alberta
  14. Edmonton, Alberta
  15. Toronto, Ontario
  16. Montreal, Quebec
  17. Montreal, Quebec
  18. Atlanta, Georgia
  19. Atlanta, Georgia
  20. Atlanta, Georgia
  21. Chicago, Illinois
  22. Chicago, Illinois
  23. Iowa City, Iowa
  24. New Orleans, Louisiana
  25. New Orleans, Louisiana
  26. Boston, Massachusetts
  27. New York, New York
  28. Durham, North Carolina
  29. Durham, North Carolina
  30. Durham, North Carolina
  31. Nashville, Tennessee
  32. Dallas, Texas
  33. Dallas, Texas
  34. Dallas, Texas
ALL GENDERS
18 Years+
years
MULTIPLE SITES
Advanced Information
Descriptive Information
Brief Title  ICMJE CP-751,871 Treatment For Patients With Multiple Myeloma
Official Title  ICMJE An Open Label Phase I Study Of CP-751,871 In Patients With Multiple Myeloma
Brief Summary This study represents the first-in-human study for CP-751,871. The study aimed to define the safety, tolerability, and maximum tolerated dose of CP-751,871 in patients with multiple myeloma through a dose escalation design.
Detailed Description Not Provided
Study Type  ICMJE Interventional
Study Phase  ICMJE Phase 1
Study Design  ICMJE Allocation: N/A
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Condition  ICMJE Multiple Myeloma
Intervention  ICMJE Drug: CP-751,871
CP-751,871 was given at doses ranging from 0.025 mg/kg up to 20 mg/kg IV every 4 weeks until disease progression or lack of tolerability
Study Arms  ICMJE Experimental: Single agent CP-751,871
dose escalation design
Intervention: Drug: CP-751,871
Publications * Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status  ICMJE Completed
Actual Enrollment  ICMJE
 (submitted: October 16, 2012)		47
Original Actual Enrollment  ICMJE
 (submitted: February 15, 2012)		50
Actual Study Completion Date  ICMJE June 2008
Actual Primary Completion Date June 2008   (Final data collection date for primary outcome measure)
Eligibility Criteria  ICMJE

Inclusion Criteria:

  • Previously treated multiple myeloma with a quantifiable serum (M spike ? 1 g/dL) and/or urine (? 200 mg/24-hr) paraprotein
  • Adequate bone marrow, renal, liver and cardiac function
  • Eastern Cooperative Oncology Group [ECOG] performance status less than or equal to 2

Exclusion Criteria:

  • Prior allogeneic stem cell transplant (alloSCT)
  • Myelosuppressive chemotherapy or immunotherapy within 3 weeks prior to treatment with CP-751,871
  • Prior organ allograft
  • Concurrent use of insulin, oral hypoglycemic medication, growth hormone (GH), or growth hormone inhibitors
  • Female patients who are pregnant or lactating
Sex/Gender  ICMJE
Sexes Eligible for Study:All
Ages  ICMJE 18 Years and older   (Adult, Older Adult)
Accepts Healthy Volunteers  ICMJE No
Contacts  ICMJE Contact information is only displayed when the study is recruiting subjects
Listed Location Countries  ICMJE United States
Removed Location Countries  
 
Administrative Information
NCT Number  ICMJE NCT01536145
Other Study ID Numbers  ICMJE A4021001
Has Data Monitoring Committee No
U.S. FDA-regulated Product Not Provided
IPD Sharing Statement  ICMJE Not Provided
Responsible Party Pfizer
Study Sponsor  ICMJE Pfizer
Collaborators  ICMJE Not Provided
Investigators  ICMJE
Study Director:Pfizer CT.gov Call CenterPfizer
PRS Account Pfizer
Verification Date March 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP