Characterize Patients With Moderately Active Rheumatoid Arthritis (RA)

1. To assess the baseline (i.e. RA therapy initiation) characteristics in a real-world setting across two moderate RA cohorts: a Test Group of patients newly exposed to etanercept (Enbrel) therapy and a Control Group of patients with similar disease characteristics newly exposed to other, non-biologic therapies.
2. To assess the change over time (from baseline to the most recent follow-up) in the characteristics described at baseline in 2 British Society for Rheumatology Biologics Register (BSRBR) cohorts (i.e. moderate RA patients treated with Disease modifying anti-rheumatic drugs (DMARDs) alone versus moderate RA patients treated with Enbrel).

• Biological: etanercept
  
  This is a Non-interventional study. The data is being analyzed retrospectively. The data consists of 2 cohorts; biologic and non-biologic
  Other Name: Enrel
• Drug: methotrexate (MTX)
  
  This is a Non-interventional study. The data is being analyzed retrospectively. The data consists of 2 cohorts; biologic and non-biologic
  Other Name: non-biologic DMARD

• Biologic
  
  Intervention: Biological: etanercept
• non-biologic DMARD
  
  Intervention: Drug: methotrexate (MTX)

Inclusion Criteria:

The Test Group will be patients with rheumatoid arthritis, newly starting therapy with etanercept (Enbrel). Inclusion criteria for the exposed cohort subjects are:

• Patients aged 18 years and over at the time of diagnosis;
• Patients from the BSRBR with moderate RA as defined by a DAS28 (>3.2 and ?5.1);
• Patients who have given informed consent for long term follow-up and access to all medical records;
• Patients initiating (i.e. at leats one treatment) treatment with etanercept (Enbrel) for RA.

The Control Group:

• Patients aged 18 years and over a the time of diagnosis;
• Patients from the BSRBR with moderate RA as defined by a DAS28 (>3.2 and ?5.1);
• Patients who have given informed consent for long term follow-up and access to all medical records; Patients are receiving at least one traditional DMARD and have never been prescribed a biologic agent;

Exclusion Criteria:

Per BSRBR registry since data is retropsectively being analyzed