- Healthy male and/or female subjects between the ages of 21 and 55 years
- Body Mass Index (BMI) of 17.5 to 30.5 kg/m2; and a total body weight >45 kg (99 lbs).
- Baseline orthostatic hypotension defined as a ?20 mm Hg reduction in systolic blood
pressure (SBP), a ?10 mm Hg reduction in diastolic blood pressure (DBP) or the
development of significant postural symptoms (dizziness, lightheadedness, vertigo)
when going from the supine to standing position.
- Subjects who are currently prescribed and/or taking nitrates or nitric oxide donors
in any form on either a regular or intermittent basis.