A Randomized, Two-way, Crossover Study to Estimate the Relative Bioavailability of a Controlled-release Formulation of Oxycodone (40 mg) With Sequestered Naltrexone Compared With Immediate-release Oxycodone Tablets (20 mg) in Healthy Volunteers

• Drug: Oxycodone controlled-release test formulation
  
  single dose administration of test formulation under fasted conditions
  Other Name: ALO-02
• Drug: Immediate-release reference drug
  
  single dose administration of reference drug under fasted conditions
  Other Name: Roxicodone

• Treatment A
  
  Controlled release oxycodone test formulation 40 mg
  Intervention: Drug: Oxycodone controlled-release test formulation
• Treatment B
  
  Immediate release oxycodone reference drug 20 mg
  Intervention: Drug: Immediate-release reference drug

Inclusion Criteria:

• healthy volunteers, greater than 50 kg, able and willing to sign informed consent

Exclusion Criteria:

• Evidence of significant illness, condition affecting drug absorption, history of sleep apnea, and allergy to opioid drugs