- Patient must be 18 to 90 years of age, inclusive,
- Female patients can participate if they are surgically sterilized or postmenopausal
for at least 1 year or her sexual partner has had a vasectomy
- Female of childbearing potential has had normal menstrual periods for 3 months and
negative serum pregnancy test and agree to practice highly effective methods of birth
control during treatment and for at least 7 days after last dose
- Intraoperative/postoperative enrollment with visual confirmation (presence of pus
within the abdominal cavity) of an intra-abdominal infection associated with
peritonitis
- Confirmation of infection by surgical intervention within 24 hours of entry: evidence
of systemic inflammatory indicators; physical findings consistent with intra-abdominal
infection; supportive radiologic imaging findings of intra-abdominal infections
- Patient is diagnosed with traumatic bowel perforation undergoing surgery within 12
hours; perforation of gastroduodenal ulcers undergoing surgery within 24 hours. Other
intra-abdominal processes in which primary etiology is not likely to be infectious
- Patient has abdominal wall abscess or bowel obstruction without perforation or
ischemic bowel without perforation
- Patients whose surgery will include staged abdominal repair, or "open abdomen"
technique, or marsupialization
- Patient has suspected intra-abdominal infections due to fungus, parasites, virus or
tuberculosis
- Patient is considered unlikely to survive the 6- to 8-week study period or has a
rapidly progressive or terminal illness, including septic shock that is associated
with a high risk of mortality