- Healthy male and/or female subjects of non-child bearing potential between the ages of
18 and 55 years, inclusive (Healthy is defined as no clinically relevant abnormalities
identified by a detailed medical history, full physical examination, including blood
pressure and pulse rate
- Evidence or history of clinically significant hematological, renal (ie, recurrent
nephrolitisis), endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic,
psychiatric, neurologic, or allergic disease (including drug allergies, but excluding
untreated, asymptomatic, seasonal allergies at time of dosing).
- History of, or presence of allergic skin reactions or active skin disease (except for
subjects with acne who may be included in the study) at the time of screening.