Study of BMN 673, a PARP Inhibitor, in Healthy Adult Male Volunteers

• Experimental: Treatment A
  
  Period 1: fasted control ? Period 2: fed control
  Intervention: Drug: BMN 673
• Experimental: Treatment B
  
  Period 1: fed control ? Period 2: fasted control
  Intervention: Drug: BMN 673

Inclusion Criteria:

• Male, between the ages of 18 and 55.
• Non-smoking for at least 1 year before Screening.
• Willing and able to provide informed consent.
• Have a BMI between 18 to 30kg/m2.
• Willing and able to comply all study procedures.
• Have adequate organ function
• Sexually active patients must be willing to use an acceptable method of contraception.

Exclusion Criteria:

• History of any illness that might confound the results of the study or pose an additional risk in administering study medication to the subject.
• Current use of prescription medication or regular treatment with over-the-counter medications.
• Consumption of herbal medications or dietary supplements.
• Consumption of more that than 3 units of alcoholic beverages per day.
• Consumption of more than five 240-mL servings of coffee or other caffeinated beverage.
• History of alcohol or drug abuse or addiction within 6 months of study entry.
• Participation in a clinical Study involving administration of an investigational drug within 1 month or 5 half lives (whichever is longer).
• Donation of any blood or having had a significant loss of blood with 56 days.