Topical Ibuprofen for Delayed Onset Mulscle Soreness

• Drug: IBU BID
  
  10-cm strip of IBU 5% topical gel applied to the affected area BID (twice daily) x 3 days
• Drug: Placebo BID
  
  10-cm strip of placebo topical gel applied to the affected area BID (twice daily) x 3 days
• Drug: IBU TID
  
  10-cm strip of IBU 5% topical gel applied to the affected area TID (three times daily) x 3 days
• Drug: Placebo TID
  
  10-cm strip of placebo topical gel applied to the affected area TID (three times daily) x 3 days

• Experimental: Ibuprofen 5% topical gel BID
  
  IBU BID (Treatment A)
  Intervention: Drug: IBU BID
• Placebo Comparator: Placebo topical gel BID
  
  Placebo BID (Treatment B)
  Intervention: Drug: Placebo BID
• Experimental: Ibuprofen 5% topical gel TID
  
  IBU TID (Treatment C)
  Intervention: Drug: IBU TID
• Placebo Comparator: Placebo topical gel TID
  
  Placebo TID (Treatment D)
  Intervention: Drug: Placebo TID

Inclusion Criteria:

Males or females, 18 to 65 years of age, who have not engaged in upper extremity fitness activities for a minimum of 3 months prior to entry in the study; subjects must be willing to refrain from use of pharmacologic or non pharmacologic treatments (ie, heat, ice, massage) and other forms of soreness relief during the study

Exclusion Criteria:

Use of corticosteroids or short- or long-acting non-steroidal anti-inflammatory drugs