- Healthy subjects
- Non-dependent, recreational opioid users
- Must include at least one of these routes of administration: intranasal use on at
least 3 occassions in the past year or intravenous use on at least 1 occasion in the
past year before Screening (Visit 1).
- Diagnosis of substance and/or alcohol dependence
- Subject has participated in, is currently participating in, or seeking treatment for
substance and/or alcohol related disorder
- History of sleep apnea.