Eligibility criteria
Condition
Non-small Cell Lung Cancer
Sex
Females and Males
Age
18 + years
Inclusion criteria
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- Evidence of histologically confirmed, advanced NSCLC (stage IIIB/IV).
- Evidence of T790M mutation to enroll in Cohort A.
- Evidence of measurable disease by radiographic technique.
- Adequate organ function.
Exclusion criteria
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- Patients with T790M mutation who stopped any prior EGFR-directed therapy without
evidence of disease progression.
- Symptomatic brain metastases.
- Uncontrolled or significant cardiovascular disease.
- Pregnant or breastfeeding.