A Pharmacokinetic Study of Three Different Particle Sizes of PH-797804

• Experimental: PH-797804 PARTICLE SIZE 9-11UM
  
  Intervention: Drug: PH-797804
• Experimental: PH-797804 PARTICLE SIZE 9-11UM WITH SLS
  
  Intervention: Drug: PH-797804
• Experimental: PH-797804 PARTICLE SIZE <= 20UM
  
  Intervention: Drug: PH-797804
• Experimental: PH-797804 PARTICLE SIZE <= 20UM WITH SLS
  
  Intervention: Drug: PH-797804
• Experimental: PH-797804 PARTICLE SIZE <= 5UM
  
  Intervention: Drug: PH-797804
• Experimental: PH-797804 PARTICLE SIZE <= 5UM WITH SLS
  
  Intervention: Drug: PH-797804

Inclusion Criteria:

• Healthy male subjects and/or healthy female subjects of non-child bearing potential between the ages of 18 and 55 years (inclusive). Healthy is defined as no clinically relevant abnormalities identified by a detailed medical history, full physical examination, including blood pressure and pulse rate measurements, 12-lead ECG and clinical laboratory tests.
• Body Mass Index (BMI) of 17.5 to 30.5 kg/m2; and a total body weight > 50 kg (110 lbs).

Exclusion Criteria:

• Evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease (including drug allergies, but excluding untreated, asymptomatic, seasonal allergies at time of dosing).
• A positive urine drug screen.
• History of regular alcohol consumption exceeding 14 drinks/week for males.