A Study to Evaluate Safety, Toleration and Time Course of Plasma Concentration of Multiple Oral Doses of PF-06273340 in Healthy Subjects of Two AgeGroups, Aged 18-55 Years (Group 1) and Aged 56-75 Years (Group 2)

• Drug: PF-06273340
  Tablets, 100 mg TID, 14 days
• Drug: Placebo
  Tablets, TID, 14 days
• Drug: PF-06273340
  Tablets, to be decided dose, TID or titration, 14 days
• Drug: Placebo
  Tablets, TID or titration, 14 days

• Experimental: Group 1: Cohort 1
  Interventions:

  • Drug: PF-06273340
  • Drug: Placebo
• Experimental: Group 1: Cohort 2
  Interventions:

  • Drug: PF-06273340
  • Drug: Placebo
• Experimental: Group 1: Cohort 3
  Interventions:

  • Drug: PF-06273340
  • Drug: Placebo
• Experimental: Group 2: Cohort 4
  Interventions:

  • Drug: PF-06273340
  • Drug: Placebo
• Experimental: Group 1: Cohort 5
  Interventions:

  • Drug: PF-06273340
  • Drug: Placebo
• Experimental: Group 2: Cohort 6
  Interventions:

  • Drug: PF-06273340
  • Drug: Placebo

Inclusion Criteria:

• For Group 1 specific: Healthy male and/or female subjects of non-childbearing potential between the ages of 18 and 55 years, inclusive (Healthy is defined as no clinically relevant abnormalities identified by a detailed medical history, full physical examination, including blood pressure and pulse rate measurement, 12-lead ECG and clinical laboratory tests).
• For Group 2 specific: Healthy male and/or female subjects of non-childbearing potential between the ages of 56 and 75 years, inclusive. Subjects must be in reasonably good health as determined by the investigator based on a detailed medical history, full physical examination (including blood pressure and pulse rate measurement), 12-lead ECG and clinical laboratory tests. Subjects with mild, chronic, stable disease (eg, osteoarthritis) may be enrolled if deemed medically prudent by the investigator. In order to ensure an age range relevant to the osteoarthritis (OA) population, at least 50% of the subjects enrolled in these cohorts must be 60 years of age and above at Screening.
• For Group 2 specific: Subjects taking daily prescription or non-prescription medications for management of acceptable chronic medical conditions must be on a stable dose of these, as defined by non change in dose for the 3 months prior to the first dose of study medication and no planned changes during the conduct of the study.

Exclusion Criteria:

• Evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease (including drug allergies, but excluding untreated, asymptomatic, seasonal allergies at the time of dosing).
• Any condition possibly affecting drug absorption (eg, gastrectomy).