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A Study of the Safety, Tolerability, Pharmacokinetics, And Effects On Histamine-Induced Wheal Of PF-05180999 In Healthy Adults

Last updated on March 14, 2019

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Study Location
Pfizer Investigational Site
St. Paul, Minnesota, 55114 United States
Contact
1-800-718-1021
Eligibility criteria
Condition
The disease, disorder, syndrome, illness, or injury that is being studied.
Migraine
Sex
Male
Age
Pediatric Trials: 0-17 Years
Adult Trials: 18+ Years
18-55 years
Inclusion criteria
The factors, or reasons, that allow a person to participate in a clinical study.
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- Healthy male subjects between the ages of 18 and 55 years

- No history of clinically-relevant atopic or dermatological disease

- Positive reaction to intradermal injection of histamine

Exclusion criteria
The factors, or reasons, that prevent a person from participating in a clinical study.
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- Subjects with screening laboratory test results that deviate from the upper and/or
lower limits of the reference or acceptable range. The exception is that all liver
function tests must not exceed the upper limit of normal.

- Subjects with evidence of, or history of, hepatic disorder, including acute or chronic
hepatitis B or hepatitis C

- Intolerance to intradermal histamine injection.

- Subjects with dark skin (Part B only).

NCT01981499
Pfizer
Terminated
A Study of the Safety, Tolerability, Pharmacokinetics, And Effects On Histamine-Induced Wheal Of PF-05180999 In Healthy Adults

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