- Subjects who expected to suffer at least one acute attack of migraine, with or without
aura, each 6 weeks (The diagnosis of migraine was to comply with the criteria proposed
by the International Headache Society (IHS))
- Subjects capable of taking medication as outpatients, and recording the effects of
- Pregnant or breast-feeding women
- Migraine subjects who also suffered from concomitant frequent (non-migrainous)
headache, defined as more than six attacks per month on average.