- Healthy Japanese male and/or female subjects of non-childbearing potential.
- Body Mass Index of 17.5 to 30.5 kg/m2; and a total body weight >50 kg.
- History of sensitivity to lorazepam or other benzodiazepines.
- Evidence or history of acute narrow-angle glaucoma or sleep apnea syndrome.
- Significant psychiatric disorder, recurrent episodes of severe depression, or
subjects with serious suicidal risk.