Eligibility criteria
Condition
Neoplasms, Triple-Negative Breast Cancer
Sex
Females and Males
Age
18 + years
Inclusion criteria
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- Diagnosis of solid tumor that is advanced/metastatic and resistant to standard therapy
or for whom no standard therapy is available
- Performance Status of 0 or 1
- Adequate bone marrow, kidney, and liver function
- Part 2 includes advanced triple negative breast cancer patients.
Exclusion criteria
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- Brain metastases requiring steroids
- Major surgery, radiation therapy, or systemic anti-cancer therapy within 4 weeks of
study treatment start
- Active and clinically significant bacterial, fungal or viral infection