Study Of Palbociclib (PD-0332991) In Renal Impairment

• Experimental: Normal Renal Function
  
  Intervention: Drug: palbociclib
• Experimental: Mild Renal Impairment
  
  Intervention: Drug: palbociclib
• Experimental: Moderate Renal Impairment
  
  Intervention: Drug: palbociclib
• Experimental: Severe Renal Impairment
  
  Intervention: Drug: palbociclib

Inclusion Criteria:

• Personally signed and dated informed consent document.
• Renal function calculated by the Cockcroft Gault equation: normal function (CLcr >=90 mL/min), mild: CLcr >=60 mL/min and <90 mL/min, moderate: CLcr >=30 mL/min and <60 mL/min, severe: CLcr <30 mL/min but not requiring hemodialysis.
• Subjects with normal renal function matched for age, weight, gender and race to subjects in impaired renal function groups.

Exclusion Criteria:

• Any condition possibly affecting drug absorption.
• Renal allograft recipients.