Study Of Three Different Stomach Acid Reducing Agents When Given With Palbociclib (PD-0332991) And Food

• Drug: palbociclib commercial free base
  
  125 mg oral capsule single dose
• Drug: famotidine
  
  20 mg oral tablet 10 hours before and 2 hours after palbociclib
  Other Name: Pepcid
• Drug: rabeprazole
  
  2 x 20 mg oral tablets daily for 6 days then on 7th day, 4 hours after palbociclib
  Other Name: Aciphex
• Drug: antacid
  
  30 mL orally once (2h before palbociclib)
  Other Name: Mi-Acid Maximum Strength Liquid
• Drug: antacid
  
  30 mL orally once (2h after palbociclib)
  Other Name: Mi-Acid Maximum Strength Liquid

• Experimental: Cohort 1: Palbociclib under fed conditions
  
  Interventions:
  

  • Drug: palbociclib commercial free base
  • Drug: famotidine
  • Drug: rabeprazole
• Experimental: Cohort 2: Palbociclib under fed conditions
  
  Interventions:
  

  • Drug: palbociclib commercial free base
  • Drug: antacid
  • Drug: antacid

Inclusion Criteria:

• Healthy male and/or female subjects of non-childbearing potential between the ages of 18 and 55 years, inclusive.
• Body Mass Index (BMI) of 17.5 to 30.5 kg/m2; and a total body weight >50 kg (110 lbs).
• Willing and able to comply with all scheduled visits, treatment plan, laboratory tests, and other study procedures.

Exclusion Criteria:

• Evidence or history of clinically significant diseases (hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease).
• Use of tobacco or nicotine containing products within 3 months of screening.
• A positive urine drug screen.