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Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of PF-06649751 in Parkinson`s Disease

Last updated on March 14, 2019

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Study Location
Orange Coast Memorial Medical Center
Fountain Valley, California, 92708 United States
Contact
1-800-718-1021
Eligibility criteria
Condition
The disease, disorder, syndrome, illness, or injury that is being studied.
Parkinson`s Disease
Sex
Females and Males
Age
Pediatric Trials: 0-17 Years
Adult Trials: 18+ Years
30-80 years
Inclusion criteria
The factors, or reasons, that allow a person to participate in a clinical study.
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- Clinical diagnosis of idiopathic Parkinson's Disease with at least 2 out of 3 cardinal
characteristics (tremor, rigidity, bradykinesia)

- Mini-Mental State Examination (MMSE) ≥ 25

- Hoehn & Yahr Stage I-III inclusive

- Documented history of end of L-Dopa wearing OFF

- Cohort 5 only: History of dyskinesia following L-Dopa dosing and Score of at least 2
on Part IV, item 4.2 (functional impact of dyskinesia) of the MDS-UPDRS

Exclusion criteria
The factors, or reasons, that prevent a person from participating in a clinical study.
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- Atypical/secondary parkinsonism

- History of surgical intervention for Parkinson's Disease

- Dementia/cognitive impairment that can interfere with study assessments

NCT02224664
Pfizer
Completed
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of PF-06649751 in Parkinson`s Disease

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