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A Study Evaluating PF-03084014 In Patients With Advanced Breast Cancer With Or Without Notch Alterations

Last updated on March 15, 2019

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Study Location
Stanford Cancer Institute
Stanford, California, 94305 United States
Contact
1-800-718-1021
Eligibility criteria
Condition
The disease, disorder, syndrome, illness, or injury that is being studied.
Triple Negative Breast Neoplasms
Sex
Female
Age
Pediatric Trials: 0-17 Years
Adult Trials: 18+ Years
18 + years
Inclusion criteria
The factors, or reasons, that allow a person to participate in a clinical study.
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- Histological or cytological diagnosis of triple negative breast cancer (TNBC) with
evidence of a) metastatic or b) locally recurrent advanced disease that is not
amenable to resection or radiotherapy with curative intent.

- Availability of an original diagnostic tumor tissue or the most recent metastatic
tumor biopsies (archival biopsy or de novo biopsy) and a peripheral blood sample for
Notch receptors genomic profiling

Exclusion criteria
The factors, or reasons, that prevent a person from participating in a clinical study.
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- Known brain metastases.

- Prior treatment with gamma secretase inhibitor or other Notch signaling inhibitor.

NCT02299635
Pfizer
Terminated
A Study Evaluating PF-03084014 In Patients With Advanced Breast Cancer With Or Without Notch Alterations

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Triple Negative Breast Neoplasms
NCT02299635
Females
18+
Years
Multiple Sites

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Contact a representative by phone, email, or visiting the study website. Please see the references below:

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Pfizer Clinical Trials Contact Center

1-800-718-1021

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