- 1. Histological confirmation of nonsquamous NSCLC, with any TNM stage. 2. Available and
sufficient tissue sample for ALK testing 3.Tissue samples are less than 5 years old
4.Routinely processed formalin-fixed, paraffin-embedded tissue samples only (see exclusion
criteria pertaining to tissue samples).
5.Histological sections mounted on glass slides must not be older than 3 months 6.Age > 18
years 7.Any ECOG Performance status 8.Still alive, or death confirmed before inclusion, or
is unknown 9.Disease diagnosis and/or treatment in one of the centers, in the last 5 years,
assigned to participate in the study; 10.Written informed consent for general
investigational testing was previously obtained, or specifically obtained for this
retrospective epidemiology study, or having a documented waiver for the Informed consent
document use, as required by local regulatory authorities, &/or Research Ethics
committee/Institutional Review Board.
- 1- Tumor tissue samples older than 5 year period or samples not properly stored.
2-Tumor tissue samples fixed by using AFA, B5, Bouin's, 95% ETOH, & alcohol fixatives.
3-Under-fixed tissue samples (i.e.
subject to any decalcification processes. 5-Recycled paraffin-embedded tissue samples.
6-Cut slides stored longer than 3 months. 7-Insufficient tissue samples with less
tumor cells & high amount of necrosis.