- Female subjects of non-childbearing potential and male subjects between the ages of 40
and 80 years, inclusive
- Subjects with a diagnosis, for at least 6 months, of moderate to severe COPD and who
meet the criteria for Stage II-III disease
- Subjects must have a smoking history of at least 10 pack-years
- Current evidence or history within the previous 6 months of any clinically significant
disease (other than COPD) or abnormality in the opinion of the Investigator that would
put the subject at risk or which would compromise the quality of the study data
- A COPD exacerbation requiring treatment with oral steroids or hospitalization for the
treatment of COPD within 3 months of Screening