Eligibility criteria
Condition
Myelodysplastic Syndrome, Acute Myeloid Leukemia
Sex
Females and Males
Age
18 + years
Inclusion criteria
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- Patients must have previously untreated MDS or AML according to the WHO 2016
classification.
- MDS patients must have Intermediate (>3 to 4.5 points), High Risk (>4.5 - 6) or Very
High Risk (>6 points) disease according to the Revised International Prognostic
Scoring System 2012.
- Clinical indication for treatment with azacitidine for MDS or AML.
Exclusion criteria
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- Patients with AML who are candidates for standard induction chemotherapy as first line
treatment.
- Patients with known active CNS leukemia.
- Prior treatment with a smoothened inhibitor (SMOi) and/or hypomethylating agent.