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A Study Of PF-03084014 In Japanese Patients With Advanced Solid Tumors

Last updated on February 17, 2019

FOR MORE INFORMATION
Study Location
Contact
1-800-718-1021
Eligibility criteria
Condition
The disease, disorder, syndrome, illness, or injury that is being studied.
Advanced Solid Tumors
Sex
Females and Males
Age
Pediatric Trials: 0-17 Years
Adult Trials: 18+ Years
18 + years
Inclusion criteria
The factors, or reasons, that allow a person to participate in a clinical study.
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- Histological or cytological diagnosis of advanced solid tumors that is resistant to
standard therapy or for which no standard therapy is available.

- Age ≥18 years.

- ECOG Performance Status (PS) must be 0 or 1.

- Adequate Bone Marrow Function

- Adequate Renal Function

- Adequate Liver Function

- Resolved acute effects of any prior therapy to baseline severity or Grade ≤1

Exclusion criteria
The factors, or reasons, that prevent a person from participating in a clinical study.
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- Patients with known brain metastases

- Major surgery within 4 weeks of starting study treatment

- Radiation therapy within 2 weeks of starting study treatment

- Systemic anti cancer therapy within 2 weeks (4 weeks for antibody) of starting study
treatment

- Previous high dose chemotherapy requiring stem cell rescue

- Prior irradiation to >25% of the bone marrow

- Prior treatment with a Notch signal inhibitor

- Known malabsorption syndrome or other condition that may impair absorption of study
medication

- Any of the following in the previous 6 months: myocardial infarction, severe/unstable
angina, coronary/peripheral artery bypass graft, symptomatic congestive heart failure,
cerebrovascular accident, transient ischemic attack or symptomatic pulmonary embolism

- Current use or anticipated need for known strong and/or moderate CYP3A4 inhibitors

- Current use or anticipated need for known strong CYP3A4 inducers

NCT02462707
Pfizer
Withdrawn
A Study Of PF-03084014 In Japanese Patients With Advanced Solid Tumors

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Questions about a trial? Call or email to reach a Pfizer Clinical Trial Contact Center

Pfizer Clinical Trials Contact Center

1-800-718-1021

[email protected]

call now

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FOR MORE INFORMATION

Contact a representative by phone, email, or visiting the study website. Please see the references below:

BY PHONE

Pfizer Clinical Trials Contact Center

1-800-718-1021

BY EMAIL

Contact

[email protected]

Call Now