First-In-Human Study Of Single And Multiple Ascending Doses Of PF-06751979

• Drug: PF-06751979 single ascending dose
  PF-06751979 administered as a single dose (solution/suspension) in cross-over fashion. Each subject may receive up to 4 study treatments (placebo and up to 3 doses of PF-06751979). The dose levels are 3 mg, 12 mg, 40 mg, 160 mg.
• Drug: Placebo single dose
  Matched Placebo solution/suspension administered as single dose.
• Drug: PF-06751979 multiple ascending dose
  PF-06751979 (solution/suspension) administered daily for 14 consecutive days to parallel cohorts. The dose levels are 5 mg, 15 mg, 50 mg.
• Drug: Placebo multiple dose
  Matched Placebo (solution/suspension)administered daily for 14 consecutive days.
• Drug: PF-06751979 multiple dose
  PF-06751979 (solution/suspension) administered daily for 14 consecutive days. The dose level is 50 mg.
• Drug: PF-06751979 multiple dose
  Matched Placebo (suspension/solution) administered daily for 14 consecutive days to parallel cohorts.

• Experimental: Single Ascending Dose Cross-over
  Single Ascending Dose in 4-way cross-over design (PF-06751979/Placebo).
  Interventions:

  • Drug: PF-06751979 single ascending dose
  • Drug: Placebo single dose
• Experimental: Multiple Ascending Dose PF-06751979
  Multiple dose administration to Healthy Subjects in parallel cohorts(PF-06751979)
  Intervention: Drug: PF-06751979 multiple ascending dose
• Placebo Comparator: Multiple Ascending Dose Placebo
  Multiple dose administration to Healthy Subjects in parallel cohorts(Placebo)
  Interventions:

  • Drug: Placebo multiple dose
  • Drug: PF-06751979 multiple dose
• Experimental: Multiple Dose Elderly PF-06751979
  Multiple dose administration to Healthy Elderly Subjects (PF-06751979)
  Intervention: Drug: PF-06751979 multiple dose
• Placebo Comparator: Multiple Dose Elderly Placebo
  Multiple dose administration to Healthy Elderly Subjects (Placebo)
  Intervention: Drug: Placebo multiple dose

Inclusion Criteria:

• Healthy male and/or female subjects of non-childbearing potential between the ages of 18 and 55 years or between the ages of 60 and 85 years, inclusive.
• Body Mass Index (BMI) of 17.5 to 32 kg/m2; and a total body weight >50 kg (110 lbs) at Screening.
• Evidence of a personally signed and dated informed consent document indicating that the subject or a legally acceptable representative has been informed of all pertinent aspects of the study.

Exclusion Criteria:

• Evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease (including drug allergies, but excluding untreated, asymptomatic, seasonal allergies at the time of dosing).
• Male subjects with partners currently pregnant; male subjects able to father children who are unwilling or unable to use a highly effective method of contraception as outlined in this protocol for the duration of the study and for at least 28 days after the last dose of investigational product.
• Unwilling or unable to comply with the Lifestyle Guidelines described in this protocol.
• Subjects who are investigational site staff members directly involved in the conduct of the study and their family members, site staff members otherwise supervised by the Investigator, or subjects who are Pfizer employees directly involved in the conduct of the study.
• Any severe acute or chronic medical or psychiatric condition including recent (within the past year) or active suicidal ideation or behavior or laboratory abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and, in the judgment of the Investigator, would make the subject inappropriate for entry into this study.