- Subjects must have a clinical diagnosis of idiopathic Parkinson's disease and presence
of at least 2 out of 3 cardinal characteristics (tremor, rigidity and/or
bradykinesia).
- Must be Hoehn & Yahr Stage II-III inclusive and experiencing motor fluctuations in the
form of end-of-dose wearing off during the morning hours or early morning akinesia.
- Subjects should be able to recognize their "wearing off" symptoms and verify that they
usually improve after their next dose of Parkinson's disease medication. Subjects
should be able to recognize drug-induced dyskinesias and verify whether or not they
are troublesome.
- History or clinical features consistent with an atypical parkinsonian syndrome, (for
example: ataxia, dystonia, clinically significant orthostatic hypotension.