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A Study to Assess The Effects Of Effexor XR On Cardiac Repolarization In Healthy Adult Subjects

Last updated on March 14, 2019

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Study Location
Pfizer New Haven Clinical Research Unit
New Haven, Connecticut, 06511 United States
Contact
1-800-718-1021
Eligibility criteria
Condition
The disease, disorder, syndrome, illness, or injury that is being studied.
Healthy Subjects
Sex
Females and Males
Age
Pediatric Trials: 0-17 Years
Adult Trials: 18+ Years
18-55 years
Inclusion criteria
The factors, or reasons, that allow a person to participate in a clinical study.
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1. Healthy female subjects and/or male subjects who at the time of screening, are between
the ages of 18 and 55 years, inclusive. Healthy is defined as no clinically relevant
abnormalities identified by a detailed medical history, full physical examination,
including blood pressure and pulse rate measurement, 12 lead ECG or clinical
laboratory tests.

2. Body Mass Index (BMI) of 17.5 to 30.5 kg/m2; and a total body weight >50 kg (110 lbs).

3. Evidence of a personally signed and dated informed consent document indicating that
the subject has been informed of all pertinent aspects of the study.

4. Subjects who are willing and able to comply with all scheduled visits, treatment plan,
laboratory tests, and other study procedures.

5. Based on CYP2D6 genotyping, the subject is required to be classified as a CYP2D6
extensive metabolizer (EM).

Exclusion criteria
The factors, or reasons, that prevent a person from participating in a clinical study.
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1. Evidence or history of clinically significant hematological, renal, endocrine,
pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or
allergic disease (including drug allergies, but excluding untreated, asymptomatic,
seasonal allergies at time of dosing).

2. Any condition possibly affecting drug absorption (eg, gastrectomy).

3. A positive urine drug screen.

4. History of regular alcohol consumption exceeding 7 drinks/week for females or 14
drinks/week for males (1 drink = 5 ounces (150 mL) of wine or 12 ounces (360 mL) of
beer or 1.5 ounces (45 mL) of hard liquor) within 6 months of Screening.

5. Treatment with an investigational drug within 30 days (or as determined by the local
requirement) or 5 half lives preceding the first dose of study medication (whichever
is longer).

6. Screening supine blood pressure > 140 mm Hg (systolic) or > 90 mm Hg (diastolic),
following at least 5 minutes of rest. If BP is >140 mm Hg (systolic) or >90 mm Hg
(diastolic), the BP should be repeated two more times and the average of the three BP
values should be used to determine the subject's eligibility.

7. Screening supine 12 lead ECG demonstrating QTcF >450 msec or a QRS interval >120 msec.
If QTcF exceeds 450 msec, or QRS exceeds 120 msec, the ECG should be repeated two more
times and the average of the three QTcF or QRS values should be used to determine the
subject's eligibility.

8. Pregnant female subjects; breastfeeding female subjects; male subjects with partners
currently pregnant; male subjects able to father children and female subjects of
childbearing potential who are unwilling or unable to use 2 highly effective methods
of contraception as outlined in this protocol for the duration of the study and for at
least 28 days after the last dose of investigational product or longer based upon the
compound's half-life characteristics.

9. Use of prescription or nonprescription drugs and dietary supplements within 7 days or
5 half lives (whichever is longer) prior to the first dose of study medication.

10. As an exception, acetaminophen/paracetamol may be used at doses of less than 1 g/day.
Limited use of non prescription medications that are not believed to affect subject
safety or the overall results of the study may be permitted on a case by case basis
following approval by the sponsor.

Herbal supplements and hormone replacement therapy must be discontinued at least 28
days prior to the first dose of study medication.

11. Blood donation (excluding plasma donations) of approximately 1 pint (500 mL) or more
within 56 days prior to dosing.

12. History of sensitivity to heparin or heparin induced thrombocytopenia.

13. History of known QTc prolongation or ECG abnormalities.

14. Individuals with known hypersensitivity reactions to venlafaxine, desvenlafaxine or
SSRI (Selective serotonin reuptake inhibitors) or SNRI (Selective serotonin and
norepinephrine reuptake inhibitors).

15. Individuals with a known hypersensitivity to moxifloxacin or quinolones.

NCT02637193
Pfizer
Completed
A Study to Assess The Effects Of Effexor XR On Cardiac Repolarization In Healthy Adult Subjects

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Pfizer Clinical Trials Contact Center

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[email protected]

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