1. Patient ≥18 years diagnosed with COPD (any stage, the subgroups for the analysis would
be based on COPD severity grade)
2. Ability to understand and complete the required QoL questionnaires
3. At least 2 years of clinical history available that includes records of previous
moderate/severe exacerbations, influenza and pneumococcal vaccination history
comorbidities and previous treatments.
4. Spirometry data (maximum 6 months old, or if not available at enrollment, to be
performed as per normal clinical practice at visit 1 +/- one month)
1. Impossibility to perform prospective follow up
2. Present any immunocompromising condition
3. Present any other respiratory diseases as co-morbidity (subjects with overlap
syndromes COPD-asthma will be excluded. Mixed phenotype defined as: symptoms of
increased variability of airflow and incompletely reversible airflow obstruction)