- Male and/or female subjects of non-child bearing potential, 18 years to 75 years of
age inclusive at the time of informed consent
- Only women of non-child bearing potential
- Diagnosis of active UC (histologic) prior to study entry for a minimum of 4 months
- Subjects with moderate to severe, active UC as defined by Mayo stool frequency
subscore of > 1, and/or rectal bleeding subscore of > 1
- Mayo Endoscopic subscore of at least 2 for a portion of inflamed segment
- Clinically significant/unstable clinical conditions (eg. cancer hematological,
endocrine etc)
- Active enteric infections
- Other forms of colitis such as Crohn's disease, infectious colitis etc