Eligibility criteria
Condition
Healthy
Sex
Male
Age
18-55 years
Inclusion criteria
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Inclusion Criteria:
- Healthy as determined by the investigator on the basis of medical history, physical
examination, clinical laboratory test results, vital signs, and 12?lead
electrocardiogram (ECG).
- Smoker of at least 1 pack or more of cigarettes per day (20 plus or minus 3
cigarettes) for more than 1 year as determined by history.
Exclusion criteria
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Exclusion Criteria:
- Any diagnosed bleeding disorder.
- Any major surgical procedure within 6 months before study day 1.
- Any history of major bleeding (eg, bleeding peptic ulcer) within 1 year before study
day 1.