- Patients with T2DM who are treated with metformin and/or diet and exercise
- HbA1c greater than or equal to 7% and less than or equal to 10.5%
- Total body weight >50 kg (110 lb) with BMI 24.5 to 45.4 kg/m^2
- Any condition possibly affecting drug absorption
- Diagnosis of Type 1 diabetes
- History of myocardial infarction, unstable angina, arterial revascularization, stroke,
heart failure, or transient ischemic attack within 6 months of screening
- Any malignancy not considered cured
- Personal or family history of MTC or MEN2, or participants with suspected MTC
- Acute pancreatitis or history of chronic pancreatitis
- Symptomatic gallbladder disease
- Known medical history of active proliferative retinopathy and/or macular edema
- Known medical history of active liver disease, including chronic active hepatitis B or
C, or primary biliary cirrhosis
- Known history of HIV
- Supine blood pressure greater than or equal to 180 mmHg (systolic) or greater than or
equal to 105 mmHg (diastolic)
- Clinically relevant ECG abnormalities
- Positive urine drug test