Study Of Single And Multiple Ascending Doses Of PF-07054894 In Healthy Adult Participants

• Drug: PF-07054894
  Participants will receive oral ascending doses
• Drug: Placebo
  Participants will receive matching placebo

• Experimental: PF-07054894
  Participants will receive single or multiple ascending doses of oral PF-07054894
  Intervention: Drug: PF-07054894
• Placebo Comparator: Placebo
  Participants will receive matching placebo
  Intervention: Drug: Placebo

Inclusion Criteria:

• Male and female (of non-child bearing potential) participants must be 18 to 55 years of age, inclusive, and with BMI of 17.5 to 30.5 kg/m2; and a total body weight >50 kg (110 lb).
• Male and female of non-child bearing potential participants who are overtly healthy as determined by medical evaluation.
• Participants must be willing to avoid direct sunlight exposure or any high intensity ultraviolet light exposure, from admission to FU1 and to apply sun screen/lotion with a high sun protection factor, as appropriate.

Exclusion Criteria:

• Evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurological, immunological/rheumatological, or allergic diseases.
• Evidence of active or latent or inadequately treated infection with Mycobacterium tuberculosis (TB), history of HIV infection, hepatitis B, or hepatitis C.
• Other medical or psychiatric condition including recent (within the past year) or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation or, in the investigator's judgment, make the participant inappropriate for the study.
• Have a history of systemic infection requiring hospitalization, parenteral antimicrobial therapy, or as otherwise judged clinically significant by the investigator within 6 months prior to Day 1.
• History of phototoxicity and photosensitivity.