Study To Characterize Mass Balance, Absolute Bioavailability, Fraction Absorbed And Pharmacokinetics Of 14C PF-06882961

• Drug: [14C]PF-06882961, 50 mg
  A single oral dose of [14C]PF-06882961, will be administered as a liquid formulation.
• Drug: PF-06882961, 50 mg and [14C]PF-06882961, 100 ug
  A single, oral, unlabeled dose of PF-06882961, 50 mg will be administered as a liquid formulation. Approximately 3 hours after the administration of the unlabeled oral dose, a single dose of [14C]PF-06882961 will be administered via intravenous infusion.

• Experimental: Oral [14C]PF-06882961, 50 mg
  In this arm, a single oral dose of [14C]PF-06882961, 50 mg will be administered as a liquid formulation.
  Intervention: Drug: [14C]PF-06882961, 50 mg
• Experimental: Oral PF-06882961 50 mg and intravenous [14C]PF-06882961 100 ug
  In this arm, single oral dose of unlabeled PF-06882961, 50 mg will be administered as a liquid formulation. Approximately 3 hours after the administration of the unlabeled oral dose, a single dose of [14C]PF-06882961, 100 ug, will be administered via intravenous infusion.
  Intervention: Drug: PF-06882961, 50 mg and [14C]PF-06882961, 100 ug

Inclusion Criteria:

• Male participants between 18 to 54 years of age
• Healthy and capable of signing informed consent document
• Willing to comply to all scheduled visits, lab tests, lifestyle considerations and study procedures
• Body mass index (BMI) of 17.5 to 30 kg/m2; and a total body weight ?50 kg (110 lb).

Exclusion Criteria:

• acute or chronic medical or psychiatric condition including recent (within the past year)
• Surgical procedures like gastrectomy, cholecystectomy, Irregularity in bowel movements
• Use of prescription or non-prescription drugs and dietary and herbal supplements within 14 days prior to the first dose of investigational product.
• Previous administration with an investigational drug within 60 days (or as determined by the local requirement) preceding the first dose of investigational product used in this study.
• Known prior participation in a trial involving PF-06882961 or known intolerance to a GLP-1R agonist.
• A positive urine drug test on screening or Day -1.
• Screening supine blood pressure (BP) ?140 mm Hg (systolic) or ?90 mm Hg (diastolic), following at least 5 minutes of supine rest. If BP is ?140 mm Hg (systolic) or ?90 mm Hg (diastolic), the BP should be repeated 2 more times and the average of the 3 BP values should be used to determine the participant's eligibility.
• Participants with abnormalities in clinical laboratory tests including ECGs, vital signs, liver function tests, myocardial infarction
• Positive testing for human immunodeficiency virus (HIV), hepatitis B surface antigen (HBsAg), or hepatitis C antibody (HCVAb). Hepatitis B vaccination is allowed.
• History of alcohol or tobacco abuse or binge drinking and/or any other illicit drug use or dependence within past 6 months.
• Subjects whose occupation requires exposure to radiation or monitoring of radiation exposure.
• Blood donation (excluding plasma donations) of approximately 1 pint (500 mL) or more within 60 days prior to dosing.
• History of sensitivity to heparin or heparin-induced thrombocytopenia only if heparin is planned to flush intravenous catheters.
• Investigator site staff members directly involved in the conduct of the study and their family members, site staff members otherwise supervised by the investigator, or Pfizer employees, including their family members, directly involved in the conduct of the study.