A Study of Single Ascending Doses of PF-07258669 in Healthy Adult Participants

• Drug: PF-07258669
  PF-07258669 will be prepared as an oral solution and/or suspension given in escalating single doses to be determined
• Drug: Placebo
  Matching placebo will be prepared as an oral solution and/or suspension given in each cohort

• Experimental: Cohort 1
  Single dose administration of PF-06842874 and placebo; Within a cohort, participants will receive 3 doses of PF-07258669 and 1 dose of placebo.
  Interventions:

  • Drug: PF-07258669
  • Drug: Placebo
• Experimental: Cohort 2
  Single dose administration of PF-06842874 and placebo; Within a cohort, participants will receive 3 doses of PF-07258669 and 1 dose of placebo.
  Interventions:

  • Drug: PF-07258669
  • Drug: Placebo
• Experimental: Cohort 3
  Single dose administration of PF-06842874 and placebo; Within a cohort, participants will receive 3 doses of PF-07258669 and 1 dose of placebo.
  Interventions:

  • Drug: PF-07258669
  • Drug: Placebo

Inclusion Criteria:

• Female participants of non-child bearing potential and male participants and who are overtly healthy as determined by medical evaluation including medical history, physical examination, neurological examination, laboratory tests, and cardiac monitoring.
• Participants who are willing to avoid direct sunlight exposure or any high intensity ultraviolet light exposure from admission to the follow-up contact and to apply sunscreen/lotion with a high sun protection factor, as appropriate.
• BMI of 17.5 to 30.5 kg/m2; and a total body weight >50 kg (110 lb).

Exclusion Criteria:

• Evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurological, or allergic disease (including drug allergies, but excluding untreated, asymptomatic, seasonal allergies at the time of dosing), as well as presence of lipid panel abnormalities (eg, hypercholesterolemia, hypertriglyceridemia).
• Evidence of history of orthostatic hypotension or symptomatic bradycardia.
• Use of prescription or nonprescription drugs and dietary and herbal supplements within 7 days or 5 half-lives (whichever is longer) prior to the first dose of study intervention.
• Previous administration with an investigational drug within 30 days (or as determined by the local requirement) or 5 half-lives preceding the first dose of study intervention used in this study (whichever is longer).
• Current findings or documented past history of blood pressure values <90 mmHg systolic or <50 mmHg diastolic.
• Any lipid panel parameter (ie, total cholesterol, triglycerides, HDL, and/or LDL) ?1.25× ULN.