ABOUT THIS STUDY
Part 1 (Healthy Volunteer Cohorts):
- BMI of 17.5 to 30.5 kg/m2; and BW>50 kg (110 lbs)
- Overtly healthy as determined by medical evaluation including medical history, physical examination, vital sign assessments, temperature, 12-lead ECGs, laboratory tests
- Japanese cohort: healthy adults of Japanese descent, where parents and grandparents are Japanese
- Capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the ICD and in this protocol
Part 2 (Atopic Dermatitis Cohort):
- Evidence of active, latent, or inadequately treated TB.
- History of or positive result for HIV or hepatitis infection. Positive Covid-19 test
- Significant medical or psychiatric condition, including suicidal ideation (C-SSRS
screening assessment noting suicidal ideation in prior 6 months is not eligible).
- H/o or current endocrine disease.
- History of systemic infection requiring hospitalization, parenteral antimicrobial
treatment or considered significant by Investigator.
- History of or current malignancy, with the exception of non-metastatic BCC, squamous
cell skin or cervical in situ.
- Currently have active forms of other inflammatory skin diseases.
- Have history of or current evidence of skin disease at the time of Day 1 that would
interfere with evaluation of atopic dermatitis or response to treatment.
- Have active chronic or acute skin infection requiring treatment with systemic
antibiotics, antivirals, antiparasitics, antiprotozoals, or antifungals within 2 weeks
prior to Day 1, or superficial skin infections within 1 week prior to Day 1.
- Score of >5 on the Fitzpatrick Skin Type Assessment.
- History of anaphylaxis with the exception of participants with sensitivity and/or
anaphylaxis only to a single, avoidable allergen.
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