Staff Engineer, Sr. Manager
- United States - Massachusetts - Cambridge
- United States - Connecticut - Groton
- United States - Massachusetts - Andover
- United States - New York - New York City
ROLE SUMMARY
Pfizer's committed to the application of computational science in the areas of drug discovery and development. As part of this mission, we have recently embarked on a large-scale migration of our computational infrastructure to cloud.
This role leverages extensive experience in cloud engineering and DevOps and requires a hands-on approach to designing and delivering robust High Performance Computing (HPC) solutions supporting computational workloads across the organization.
We are seeking an experienced individual to drive architecture, infrastructure automation, migration and operational excellence. You will collaborate with HPC engineers and scientific computing specialists to develop scalable cloud native infrastructure that underpins modernization of the scientific computing platform.
ROLE RESPONSIBILITIES
Platform Architecture and Engineering
In this role you will design, implement, operate, and own robust and dependable infrastructure for HPC and ML/AI workloads in a cloud environment (AWS/GCP).
Lead containerization, deployment, and operation of user- and admin-facing HPC platforms (Slurm, Open On Demand, Prometheus/Grafana, batch and distributed computing platforms) across cloud environments.
Translate stakeholder input into robust, high-performance, scalable, cost effective computing platforms.
Partner with HPC specialists (engineers, administrators, and users) to capture institutional knowledge and manual processes in IaC workflows, transforming ad-hoc deployment practices into reproducible, version-controlled, automated procedures.
Automation and DevOps
Develop and maintain infrastructure automation using IaC tools like Terraform and CloudFormation to ensure repeatable environment provisioning and scaling.
Create reusable Terraform modules. Develop and enforce standards. Be a driver for implementing and maintaining all cloud infrastructure using IaC tools.
Operationalize containerized solutions using Docker and Kubernetes.
Own the full lifecycle of infrastructure management, from provisioning to operations, support, updating, and teardown of production computing platforms.
Perform troubleshooting, system analysis, and benchmarking to resolve issues and maintain a high-performance environment.
Monitoring and Reliability
Develop and maintain monitoring, logging, and alerting for the infrastructure (e.g., CloudWatch, Prometheus/Grafana).
Design new dashboards, workflows, and utilities to improve observability, cost monitoring, workload efficiency, user, or administration experience.
Document architecture, deployment processes, and operational procedures.
Partner closely with team members to support delivery of scientific computing services including user support, Linux administration, operations, job scheduling, application management, and resource optimization.
BASIC QUALIFICATIONS
B.S. in computer science, life science, data science or similar fields.
6+ years of experience in cloud infrastructure engineering with a proven track record of developing and supporting robust IaC deployments.
Experience managing scientific computing workloads in an enterprise environment.
Advanced experience with at least one of AWS and GCP, including knowledge of core compute and storage services relevant to HPC.
Solid understanding of cloud networking, identity, and security controls.
PREFERRED QUALIFICATIONS
Prior experience with HPC deployment utilities including AWS ParallelCluster, AWS Parallel Computing Services, and Google Cloud Cluster Toolkit.
Proficiency with distributed computing environments, especially EKS/GKE/Kubernetes.
Familiarity with HPC environments, job schedulers (Slurm), HPC application containers (Docker, Singularity, Apptainer) and NVIDIA GPU computing.
Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Occasional international travel for team meetings and conferences.
OTHER JOB DETAILS:
Last Date to Apply for Job: April 14th, 2026
Work Location Assignment: Hybrid. Must be able to work from assigned Pfizer office 2-3 days per week, or as needed by the business
Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.
U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

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Each word in our purpose has meaning and reflects the value we strive to bring to patients and society:
“Breakthroughs” - These are the innovations, scientific and commercial, that we seek to deliver every day. All colleagues, regardless of role, level or location, strive for breakthroughs every day.
“Change” - We want to do more than simply improve patients’ medical conditions; we want to dramatically change their lives for the better.
“Patients’ lives” - We consider not only patients, but everyone they touch—including their families, caregivers, and friends—and everything they love to do. It’s an intentionally holistic view.
Our purpose ensures that patients remain at the center of all we do. We live our purpose by sourcing the best science in the world; partnering with others in the healthcare system to improve access to our medicines; using digital technologies to enhance our drug discovery and development, as well as patient outcomes; and leading the conversation to advocate for pro-innovation/pro-patient policies.
Every decision we make and every action we take is done with the patient in mind—and to nurture an environment where breakthroughs can thrive.
Our Values
To fully realize Pfizer’s purpose, we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.
The “how” is represented by four simple, powerful values—courage, excellence, equity, and joy—that define our company and our culture.
Courage: Breakthroughs start by challenging convention, especially in the face of uncertainty or adversity. This happens when we think big, speak up, and are decisive.
Excellence: We can only change patients’ lives when we perform at our best together. This happens when we focus on what matters, agree who does what, and measure our outcomes.
Equity: We believe that every person deserves to be seen, heard, and cared for. This happens when we are inclusive, act with integrity, and reduce healthcare disparities.
Joy: We give ourselves to our work, but it also gives to us. We find joy when we take pride, recognize one another, and have fun.
Pfizer Digital
Pfizer Digital takes immense pride in being at the forefront of innovation, harnessing cutting-edge smart technology that profoundly impacts the lives of our patients.
With the transformative potential of digital solutions, we revolutionize how we discover, develop, and deliver medicines, enabling us to achieve breakthroughs faster and more efficiently.
By streamlining and automating transactional processes, we create valuable time and resources, empowering our talented team to focus on meaningful work that truly makes a difference in healthcare and beyond.
Benefits at Pfizer
Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues. Our Pay for Performance Philosophy and Practices reward colleagues based on the contributions they make to our business.
Our Competitive Benefits Programs help our colleagues by:
- Promoting Health and Wellness to help colleagues maintain and improve their physical and mental wellbeing. Pfizer offerings include health and disability insurance, preventative health programs, medical screenings, free or reduced-cost vaccinations, discounts on Pfizer products, mental health support, nutrition and fitness counseling and more.
- Strengthening Colleagues’ Financial Security by providing company contributions to retirement plans, life insurance and financial planning education to help colleagues achieve their financial goals.
- Providing Benefits and Time off for the Moments that Matter to ensure Pfizer colleagues have the time away from the office to recharge, recover and return to work as the best version of themselves. Vacation, Holiday time and Sick time are just the beginning, with a 12 week parental leave policy for both parents of a new born, 10 day of caregiver leave for those times when your family needs you whether it’s a child, spouse or parent, bereavement leave, and additional country-specific programs.
- And so much more, depending on your country and site, Pfizer offers childcare facilities or discount programs, on-site health and/or fitness centers, movement and mindfulness solutions, “Log in for your Day” work flexibility and so much more.
For U.S. based jobs, view an overview of Pfizer’s U.S. benefits program (opens in a new window)