Senior Manager – Response Threat Operations
- United States - Pennsylvania - Collegeville
Use Your Power for Purpose
Our Global Cyber Defense team (CD) is responsible for safeguarding Pfizer’s digital assets and infrastructure through proactive threat detection, response, and risk mitigation across on-premises, cloud, and hybrid environments.
The CD organization is part of a broader security organization at Pfizer called CISO. The CISO organization secures Pfizer’s most important information assets through world class talent, top security controls and an empowered culture that serves to enable Pfizer’s mission of delivering breakthroughs that change patients’ lives.
Why This Role Matters
The Senior Manager – Response Threat Operations will report into the Response Threat Operations team and will focus on responding to network security events and building a deep understanding of cybersecurity attacks against Pfizer. The Senior Manager – Response Threat Operations will be expected to lead event correlation across large datasets, perform and drive complete attack lifecycle analysis, develop remediation plans, implement proactive and reactive countermeasures, and create innovative solutions to the security issues that face the Pfizer environment.
The Senior Manager – Response Threat Operations will have demonstrated aptitude to rapidly apply expertise in a complex business and technical environment with previous experience in investigations, analysis, and incident response. Strong business communication and project management skills are required to maintain effective internal and customer relationships.
In addition, this position is also responsible for developing appropriate security incident response actions and monitoring effectiveness metrics.
ROLE RESPONSIBILITIES
- Lead the AMER Response Threat Operations (RTO) team, providing strategic direction, operational oversight, and people leadership while fostering a high-performing, collaborative, and growth-oriented culture.
- Partner with Cyber Defense and CISO leadership to define and execute the long-term vision, strategy, and operational roadmap for threat detection, incident response, and cyber defense capabilities.
- Oversee 24x7 threat monitoring, incident response, and cyber intrusion analysis activities across global regions, ensuring effective identification, investigation, containment, and remediation of security threats.
- Drive operational excellence through process optimization, automation, metrics-driven decision making, and continuous improvement initiatives that enhance response capabilities and organizational resilience.
- Lead and develop talent through performance management, coaching, mentoring, workforce planning, hiring, and career development, ensuring the team possesses the technical capabilities required to meet evolving threat landscapes.
- Serve as a key stakeholder and regional representative for Threat Operations, partnering with business, technology, and security leaders to manage risk, communicate security impacts, and strengthen organizational security posture.
- Direct the execution of strategic programs and projects using Agile principles, ensuring efficient resource management, timely delivery, and measurable business outcomes.
- Provide technical leadership and guidance on cyber threat detection, digital forensics, malware analysis, threat intelligence, and incident response methodologies while promoting continuous learning and cybersecurity expertise across the team.
Here Is What You Need (Minimum Requirem
Bachelor's degree with 6+ years of experience, Master's degree with 5+ years of experience, or PhD with 1+ years of experience in cybersecurity, information security, computer science, or a related field.
Advanced level understanding of TCP/IP, common networking ports and protocols, traffic flow, system administration, OSI model, defense-in-depth, and common security elements.
Advanced level understanding of the life cycle of network threats, attacks, attack vectors and methods of exploitation with an understanding of intrusion set tactics, techniques, and procedures (TTPs)
Advanced level knowledge of the Windows operating system, system utilities, admin functions
Significant experience with open-source security analysis tools such as Wireshark, SNORT, Splunk, Kali Linux, Sift, REMnux etc.
Experience with Computer programming and scripting languages such as C, Python, Java, etc.
Ability to proactively solve complex problems both individually and as part of a team
Leadership skills with the ability to prioritize and execute with minimal direction or oversight
Outstanding communication skills, including the ability to write and verbally articulate industry terminology to interact at a technical level, management level and senior executive level
Organizational, planning, and administrative abilities and the ability to coordinate multiple complex projects simultaneously
Demonstrated experience in an agile work environment possessing qualities such as a collaborative mindset, adaptability to change, and a proactive problem-solving approach.
PHYSICAL/MENTAL REQUIREMENTS
Desk job, no specific physical / mental requirements
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Standard work schedule & occasional travel required (10-20% as required)
Other job details:
Work Location Assignment: Hybrid
Last date to apply: 8/3/2026

The annual base salary for this position ranges from $139,100.00 to $231,900.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 17.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.



Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.
U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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