Sr. Director, Cloud and Infrastructure Transformation
- United States - New York - New York City
Use Your Power for Purpose
At the heart of Pfizer's Digital transformation sits Infrastructure & Cloud, enabling modern cloud platforms and engineering capabilities that accelerate scientific discovery, empower researchers, and improve patient outcomes worldwide.
Pfizer is seeking a highly accomplished technology leader who combines enterprise-scale strategic thinking with deep technical expertise in cloud, infrastructure, networking, and platform engineering. This role will shape the future of Pfizer's cloud and infrastructure ecosystem, enabling AI/ML-powered research, advanced analytics, and next-generation digital capabilities that support breakthrough science and drug discovery.
The successful candidate will be equally comfortable discussing business strategy with executive leadership, guiding large-scale transformation initiatives, and engaging directly with architects and engineers on critical technical decisions. This is a leadership role for someone who has not only led transformation programs but has personally helped design, build, and scale modern cloud platforms and infrastructure capabilities.
At Pfizer, your work will directly contribute to the technologies that enable scientists to accelerate research, unlock insights from complex data, and develop innovative medicines for patients around the world.
Pfizer seeks individuals who are highly self-motivated, intellectually curious, collaborative, and committed to continuous learning and growth.
What You Will Achieve
The Senior Director, Cloud & Infrastructure Transformation serves as both a strategic technology executive and a technical thought leader for Pfizer's cloud and infrastructure landscape. This leader will define future-state infrastructure strategy while ensuring the successful execution of complex, enterprise-scale initiatives spanning cloud, networking, data center modernization, platform engineering, and AI infrastructure.
You will lead a team of senior leaders, architects, and engineering organizations while helping establish the technology vision, engineering standards, and operating models required to support Pfizer's digital future.
You will be expected to drive business outcomes through technology strategy while maintaining the technical depth and credibility necessary to guide architecture decisions, challenge assumptions, and ensure engineering excellence.
Key Responsibilities
- Define and execute Pfizer's multi-year cloud and infrastructure transformation strategy, aligning technology investments with business and scientific priorities.
- Lead enterprise-wide modernization initiatives spanning multi-cloud environments, AI/ML platforms, network transformation, infrastructure automation, and data center evolution.
- Serve as a senior technical authority, providing guidance on architecture, platform engineering, cloud operations, resiliency, security, and infrastructure modernization.
- Partner with architects and engineering leaders to evaluate and influence critical technology decisions, ensuring scalable, secure, and operationally resilient solutions.
- Drive adoption of cloud-native architectures, Infrastructure as Code, automation, observability, DevOps, and Site Reliability Engineering practices.
- Establish technology roadmaps and engineering standards that support innovation, operational excellence, and regulatory compliance.
- Build strong partnerships across Digital, Security, Research, and Business organizations to accelerate enterprise transformation initiatives.
- Lead and develop high-performing teams of Directors, Senior Managers, and technical leaders while cultivating a culture of innovation, accountability, and technical excellence. Mainly influencing to start, followed by a larger team over time.
- Influence senior executive stakeholders and drive alignment across a complex, global, matrixed organization.
- Evaluate emerging technologies and industry trends to identify opportunities that improve Pfizer's technology capabilities and business outcomes.
- Balance strategic priorities, execution risks, operational demands, and technical considerations to drive sustainable transformation at scale.
Leadership Expectations
Candidates should demonstrate a breadth of leadership experiences and capabilities, including:
- Influencing executive leaders, peers, and technical teams to achieve enterprise outcomes.
- Building organizational capability and developing future technology leaders.
- Creating an environment that promotes innovation, accountability, collaboration, and continuous improvement.
- Leading through ambiguity and driving execution in highly complex environments.
- Translating technology strategy into measurable business impact.
- Establishing credibility with both senior executives and highly technical engineering teams.
Here Is What You Need (Minimum Requirements)
- Bachelor's degree in Computer Science, Computer Engineering, Information Technology, or related discipline.
- 12+ years of progressive leadership experience in cloud, infrastructure, networking, platform engineering, or related technology functions.
- Demonstrated success leading large-scale cloud and infrastructure transformation programs at enterprise scale.
- Deep expertise in public cloud platforms (AWS, Azure, and/or GCP), with a proven history of designing, building, and operating production environments supporting critical business workloads.
- Strong technical foundation spanning cloud architecture, networking, platform engineering, infrastructure operations, automation, and security.
- Demonstrated ability to engage in architecture reviews, challenge technical design decisions, and influence engineering standards through technical expertise and credibility.
- Experience leading organizations responsible for cloud engineering, platform engineering, infrastructure automation, architecture, operations, and reliability.
- Proven success developing and leading senior technology leaders, including Senior Managers, Directors, and Architects.
- Extensive experience driving results through influence across business, security, engineering, and executive stakeholder groups.
- Expertise in cloud-native architectures, Infrastructure as Code (Terraform/OpenTofu), automation, DevOps, observability, resiliency engineering, and modern operating models.
- Strong understanding of cybersecurity, compliance, and risk management practices within large enterprise environments.
- Exceptional communication skills with the ability to translate complex technical concepts into business-focused recommendations.
- Proven ability to simultaneously lead strategic planning and execution across multiple complex initiatives.
Preferred Qualifications
- Experience building or enabling AI/ML infrastructure, advanced analytics platforms, or high-performance computing environments.
- Experience supporting research, scientific computing, or large-scale data science workloads.
- Pharmaceutical, biotechnology, healthcare, or other highly regulated industry experience.
- Advanced degree in Computer Science, Engineering, Technology Management, or Business Administration.
- Industry certifications in cloud architecture, engineering, security, or infrastructure platforms.
- Experience leading global organizations across multiple regions, cultures, and time zones.
- Experience with enterprise-scale migrations, data center exits, platform modernization initiatives, or mergers and acquisitions.
- Demonstrated success driving technology transformation through both strategic vision and deep technical leadership.
Ideal Candidate Profile
The ideal candidate is a technology strategist and engineer at heart. They have built credibility through hands-on technical leadership, can engage deeply in architectural discussions, and have successfully led large-scale transformation efforts that delivered measurable business value. They are equally effective influencing executive stakeholders, mentoring technical leaders, and driving execution across complex enterprise environments.
Most importantly, this leader brings both the strategic mindset to shape Pfizer's future and the technical depth to help build it.
Other Job Details
Last day to apply: 9/7/2026
Work location assignment: Hybrid - onsite at NY Headquarters an average of 2.5 days per week or as the business requires
10-20% Travel
Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.
U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Pfizer endeavors to make www.pfizer.com/careers accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email disabilityrecruitment@pfizer.com. This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned.
To learn more about acceptable and prohibited uses of AI during the recruitment process, please review our candidate AI-use guidelines available on Pfizer Careers.

Information & Business Tech
Breakthroughs that change patients’ lives
Research confirms what intuition tells us: that purpose-driven companies perform better, are more innovative, attract and retain the best people, and know how to unleash the power of those people. Pfizer’s purpose—Breakthroughs that change patients' lives—fuels everything we do and reflects our passion for building on our legacy as one of the greatest contributors of good to the world.
Each word in our purpose has meaning and reflects the value we strive to bring to patients and society:
“Breakthroughs” - These are the innovations, scientific and commercial, that we seek to deliver every day. All colleagues, regardless of role, level or location, strive for breakthroughs every day.
“Change” - We want to do more than simply improve patients’ medical conditions; we want to dramatically change their lives for the better.
“Patients’ lives” - We consider not only patients, but everyone they touch—including their families, caregivers, and friends—and everything they love to do. It’s an intentionally holistic view.
Our purpose ensures that patients remain at the center of all we do. We live our purpose by sourcing the best science in the world; partnering with others in the healthcare system to improve access to our medicines; using digital technologies to enhance our drug discovery and development, as well as patient outcomes; and leading the conversation to advocate for pro-innovation/pro-patient policies.
Every decision we make and every action we take is done with the patient in mind—and to nurture an environment where breakthroughs can thrive.
Our Values
To fully realize Pfizer’s purpose, we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.
The “how” is represented by four simple, powerful values—courage, excellence, equity, and joy—that define our company and our culture.
Courage: Breakthroughs start by challenging convention, especially in the face of uncertainty or adversity. This happens when we think big, speak up, and are decisive.
Excellence: We can only change patients’ lives when we perform at our best together. This happens when we focus on what matters, agree who does what, and measure our outcomes.
Equity: We believe that every person deserves to be seen, heard, and cared for. This happens when we are inclusive, act with integrity, and reduce healthcare disparities.
Joy: We give ourselves to our work, but it also gives to us. We find joy when we take pride, recognize one another, and have fun.
Pfizer Digital
Pfizer Digital takes immense pride in being at the forefront of innovation, harnessing cutting-edge smart technology that profoundly impacts the lives of our patients.
With the transformative potential of digital solutions, we revolutionize how we discover, develop, and deliver medicines, enabling us to achieve breakthroughs faster and more efficiently.
By streamlining and automating transactional processes, we create valuable time and resources, empowering our talented team to focus on meaningful work that truly makes a difference in healthcare and beyond.
Benefits at Pfizer
Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues. Our Pay for Performance Philosophy and Practices reward colleagues based on the contributions they make to our business.
Our Competitive Benefits Programs help our colleagues by:
- Promoting Health and Wellness to help colleagues maintain and improve their physical and mental wellbeing. Pfizer offerings include health and disability insurance, preventative health programs, medical screenings, free or reduced-cost vaccinations, discounts on Pfizer products, mental health support, nutrition and fitness counseling and more.
- Strengthening Colleagues’ Financial Security by providing company contributions to retirement plans, life insurance and financial planning education to help colleagues achieve their financial goals.
- Providing Benefits and Time off for the Moments that Matter to ensure Pfizer colleagues have the time away from the office to recharge, recover and return to work as the best version of themselves. Vacation, Holiday time and Sick time are just the beginning, with a 12 week parental leave policy for both parents of a new born, 10 day of caregiver leave for those times when your family needs you whether it’s a child, spouse or parent, bereavement leave, and additional country-specific programs.
- And so much more, depending on your country and site, Pfizer offers childcare facilities or discount programs, on-site health and/or fitness centers, movement and mindfulness solutions, “Log in for your Day” work flexibility and so much more.
For U.S. based jobs, view an overview of Pfizer’s U.S. benefits program (opens in a new window)