US Commercial AI, Portfolio Lead
- United States - Pennsylvania - Collegeville
- United States - New York - New York City
As we accelerate the enterprise AI agenda and scale agentic AI across the Chief Marketing Office, the AIA Organization is seeking a Senior Director Commercial AI Portfolio Lead reporting to the VP of Transformation Lead, AIA. This role serves as the single accountable leader for AI portfolio governance, value realization, and operating excellence across AI Builds to support US Marketing, Field, Market Access & Patient Services.
The role will enable a federated build model that enables approved citizen-developer teams to build agents within a centrally governed operating model led by the Commercial AI team. This leader will manage a team who will set the standards, decision rights, controls, shared registry, and planning routines required to ensure capabilities are sequenced effectively, reused where appropriate, and built in alignment with Legal & Compliance, privacy, responsible AI, security, data, and deployment expectations. This role and supporting team is responsible for partnering closely with the CIO to ensure the seamless connectivity between CIO approaches/standards and Commercial AI builds. The Senior Director and their direct reports will be responsible for architecting and operationalizing use case intake, governance and registry.
Key Responsibilities
Commercial AI Build Standards & Central Governance
- Define the centrally governed build operating model for functional-area teams , including decision rights, intake criteria, approval pathways, documentation expectations, control points, escalation triggers, and handoff requirements in support of Commercial AI builds. and in line with CIO platform standards
- Ensure all Commercial -area-built agents and AI-enabled workflows adhere to Legal & Compliance, privacy, responsible AI, security, data use, information protection, and model / prompt evaluation standards before deployment.
- Partner with CIO, Data, Legal, Privacy, Compliance, and Security teams to align build patterns, permissioning, data product usage, API access, telemetry capture, and production deployment requirements.
Portfolio Strategy & Executive Influence
- Provide strategic guidance for incubation and exploration use cases across in-scope functions, eliminating redundancy and deduplicating assets across the organization.
- Serve as senior thought partner to the VP of Transformation Lead and the AIA leadership team on AI portfolio direction, capability gaps, build sequencing, shared dependencies, and incubation / exploration investment trade-offs.
- Drive cross-functional alignment with the Business, Finance, Legal, Privacy, Compliance, Technology, Data, and Security stakeholders to ensure consistent decision-making, resource optimization, and responsible scaling.
- Set infrastructure to understand AI direction across Commercial; enabling holistic strategic planning and decision making.
Planning Governance, Shared Registry & Cross-ATC Trade-offs
- Stand up a Commercial governance model and shared AI build registry to sequence dependencies, identify reuse opportunities, manage capacity constraints, and resolve cross-ATC trade-offs.
- Use the shared registry to maintain visibility into what is being built, by whom, for which business need, using which data products, APIs, permissions, evaluation methods, telemetry, and deployment path.
- Identify overlaps, conflicts, and platform dependencies early, and drive executive-level decisions that balance speed, business value, compliance standards, user experience, and enterprise reuse.
AI Governance Council & Platform Assessment
- Lead US Commercial AI Governance as the gold standard adopted enterprise-wide, with clear governance coverage for both centrally built and functionally built agentic AI capabilities.
- Chair the Commercial AI Council and orchestrate cross-functional decision-making at the executive level.
- Continuously evolve governance standards in partnership with Legal, Privacy and Compliance to balance speed of execution with risk management.
- Lead assessments of new AI platform capabilities and features, such as Claude Cowork, evaluating fit, risk, readiness, data implications, and adoption pathway for Commercial use.
- Partner with Compliance on these assessments to confirm new capabilities meet regulatory, privacy, responsible AI, and security standards before rollout.
AI-Powered Intake, Reporting Platform & Portfolio Visibility
- Partner with CIO Organization on the end-to-end design and delivery of the AI-powered Intake & Reporting Platform, replacing manual workflows with automated submission, evaluation, prioritization, governance routing, and stakeholder reporting.
- Integrate the shared AI build registry into intake and reporting workflows to provide real-time, organization-wide visibility into portfolio status, build ownership, value capture, reusable assets, dependencies, standards compliance, and available capabilities.
- Use the platform to surface investment recommendations, incubation candidates ready for Alpha elevation, reusable patterns, and pattern-of-use signals that inform next-wave Tier 1 capability identification.
- Design the prioritization framework that evaluates initiatives across business impact, technical feasibility, data readiness, resource requirements, compliance readiness, security posture, reuse potential, and strategic alignment.
Value Realization
- Define incubation and exploration metrics and value-tracking standards adopted across the portfolio.
- Define measurement expectations for functional-area-built agents, including value hypotheses, adoption measures, usage telemetry, quality / evaluation outcomes, risk indicators, and deployment readiness.
- Drive portfolio-level course corrections from performance data, ensuring AI investments compound business value across US Commercial and the CMO.
AI-First Operating Model & Cross-Functional Leadership
- Embed AI-first operating principles within the function, leveraging AI and automation to scale governance, intake, reporting, registry management, evaluation routines, stakeholder engagement, and executive decision support.
- Model AI-first as a leadership behavior others in the organization replicate, demonstrating measurable productivity and capability gains within the function.
- Direct Commercial and CMO colleagues to ensure governance, intake, build standards, town-planning routines, registry requirements, and value-tracking standards are embedded in process without slowing execution.
- Build, mentor, and lead a cross-functional team spanning portfolio management, governance, standards, and enablement, including effective indirect and matrixed leadership.
- Absorb and integrate portfolio and governance work from the newly incorporated Digital team, aligning processes and standards under one operating model.
Basic Qualifications
- BA/BS with 12+ years of progressive experience leading cross-functional commercial, digital, technology, governance, and/or AI initiatives at scale (graduate degrees can substitute for experience).
- Demonstrated experience leading enterprise governance, portfolio, or Center of Excellence functions in complex, matrixed organizations.
- Track record of executive-level stakeholder engagement, influence, decision facilitation, and trade-off management across business, technology, data, legal, privacy, compliance, and security stakeholders.
- Experience defining operating models, standards, controls, and adoption pathways that enable distributed teams to build consistently within centrally governed frameworks.
- Experience leading and developing teams, including indirect / matrixed teams.
- Working knowledge of AI/ML frameworks, agentic AI patterns, APIs, permissions, data products, prompt design, evaluation, telemetry, deployment patterns, and the modern AI tooling landscape.
Preferred Qualifications
- Experience standing up enterprise-wide AI, technology, or agent governance functions or Centers of Excellence.
- Experience building and operating intake, portfolio, reporting, registry, or governance workflow platforms, particularly AI-powered ones.
- Hands-on familiarity with cloud AI platforms, modern AI agent frameworks, prompt/evaluation tooling, telemetry approaches, and production deployment requirements.
- Experience creating citizen-developer governance models, low-code / no-code enablement, federated build standards, or business-builder guardrails in a regulated environment.
- Proven ability to translate complex technical, data, risk, and governance concepts to senior business stakeholders.
- Strategic thinking and creative problem-solving in ambiguous, fast-moving environments.
- Deep grounding in AI ethics, responsible AI, privacy, regulatory frameworks, and Legal & Compliance standards; regulated-industry experience strongly preferred.
Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
Other Job Details:
Last Date to Apply for Job: September 1, 2026.
Ability to travel based on business needs
This position is hybrid and requires working onsite 2 to 3 days per week
Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.
U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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To learn more about acceptable and prohibited uses of AI during the recruitment process, please review our candidate AI-use guidelines available on Pfizer Careers.

Information & Business Tech
Breakthroughs that change patients’ lives
Research confirms what intuition tells us: that purpose-driven companies perform better, are more innovative, attract and retain the best people, and know how to unleash the power of those people. Pfizer’s purpose—Breakthroughs that change patients' lives—fuels everything we do and reflects our passion for building on our legacy as one of the greatest contributors of good to the world.
Each word in our purpose has meaning and reflects the value we strive to bring to patients and society:
“Breakthroughs” - These are the innovations, scientific and commercial, that we seek to deliver every day. All colleagues, regardless of role, level or location, strive for breakthroughs every day.
“Change” - We want to do more than simply improve patients’ medical conditions; we want to dramatically change their lives for the better.
“Patients’ lives” - We consider not only patients, but everyone they touch—including their families, caregivers, and friends—and everything they love to do. It’s an intentionally holistic view.
Our purpose ensures that patients remain at the center of all we do. We live our purpose by sourcing the best science in the world; partnering with others in the healthcare system to improve access to our medicines; using digital technologies to enhance our drug discovery and development, as well as patient outcomes; and leading the conversation to advocate for pro-innovation/pro-patient policies.
Every decision we make and every action we take is done with the patient in mind—and to nurture an environment where breakthroughs can thrive.
Our Values
To fully realize Pfizer’s purpose, we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.
The “how” is represented by four simple, powerful values—courage, excellence, equity, and joy—that define our company and our culture.
Courage: Breakthroughs start by challenging convention, especially in the face of uncertainty or adversity. This happens when we think big, speak up, and are decisive.
Excellence: We can only change patients’ lives when we perform at our best together. This happens when we focus on what matters, agree who does what, and measure our outcomes.
Equity: We believe that every person deserves to be seen, heard, and cared for. This happens when we are inclusive, act with integrity, and reduce healthcare disparities.
Joy: We give ourselves to our work, but it also gives to us. We find joy when we take pride, recognize one another, and have fun.
Benefits at Pfizer
Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues. Our Pay for Performance Philosophy and Practices reward colleagues based on the contributions they make to our business.
Our Competitive Benefits Programs help our colleagues by:
- Promoting Health and Wellness to help colleagues maintain and improve their physical and mental wellbeing. Pfizer offerings include health and disability insurance, preventative health programs, medical screenings, free or reduced-cost vaccinations, discounts on Pfizer products, mental health support, nutrition and fitness counseling and more.
- Strengthening Colleagues’ Financial Security by providing company contributions to retirement plans, life insurance and financial planning education to help colleagues achieve their financial goals.
- Providing Benefits and Time off for the Moments that Matter to ensure Pfizer colleagues have the time away from the office to recharge, recover and return to work as the best version of themselves. Vacation, Holiday time and Sick time are just the beginning, with a 12 week parental leave policy for both parents of a new born, 10 day of caregiver leave for those times when your family needs you whether it’s a child, spouse or parent, bereavement leave, and additional country-specific programs.
- And so much more, depending on your country and site, Pfizer offers childcare facilities or discount programs, on-site health and/or fitness centers, movement and mindfulness solutions, “Log in for your Day” work flexibility and so much more.
For U.S. based jobs, view an overview of Pfizer’s U.S. benefits program (opens in a new window)