Sr. Director, US Team Lead, LORBRENA/BRAF Lung

ROLE SUMMARY

Pfizer Commercial Oncology is introducing the world to the next era of cancer care. With a growing portfolio of novel therapies, industry-leading R&D, and a goal of delivering eight breakthroughs by 2030 across major cancer types, we're translating cutting-edge science into market-shaping impact. Here, you'll partner with exceptional colleagues across scientific, medical, and manufacturing teams, backed by advanced digital and AI-enabled infrastructure and the authority to accelerate medicines from discovery to delivery. Guided by our values of courage, excellence, equity, and joy, you'll have the opportunity to stretch your skills and build a career that evolves with you—across teams, roles, and the Pfizer enterprise. Join us to make history — for patients, for their families, for the future. 

The US Precision Medicine Thoracic Franchise is entering its most consequential — and most complex — growth chapter. Our in-line thoracic portfolio spans two biomarker-defined populations: LORBRENA (lorlatinib) for adults with ALK-positive metastatic non-small cell lung cancer (NSCLC), and the BRAFTOVI + MEKTOVI (encorafenib + binimetinib) regimen for BRAF V600E-mutant metastatic NSCLC. Both sit inside a molecularly driven treatment landscape where the right patient is identified by a biomarker signature. Winning here means mastering precision targeting: reaching narrow, high-value, genomically defined patient populations through the exact clinicians who test for and treat them.

This is a people-management leadership role that demands a strong enterprise leader — one fluent in both commercial strategy and AI-enabled execution, and able to think and operate at the enterprise level. The colleague who leads this team will set a multi-year strategic vision, make thoughtful trade-off and resource-prioritization decisions across two brands, and influence senior leadership across the wider organization. They will operate in an AI-enabled commercial environment where machine-learning-driven customer identification, next-best-action engines, and predictive analytics reshape how, when, and to whom we deliver our message. This person will be required to leverage deep US commercial marketing experience and precision-targeting expertise to lead a highly talented team, connect targeted precision engagement activity directly to outcomes, and elevate what we are able to say — and prove — to our customers in a data-rich, AI-enabled world.

The LORBRENA/BRAF Lung Team Lead reports directly to the Franchise Lead, Precision Medicine Thoracic Franchise, and owns the continued growth of LORBRENA (including CROWN lifecycle execution) and the BRAFTOVI + MEKTOVI BRAF V600E-mutant NSCLC (lung) indication. This role requires close cross-functional coordination with the BRAFTOVI/MEKTOVI brand team to align lung-specific strategy, promotional assets, and field execution while preserving one coherent brand voice. The role requires strong leadership, collaboration, communication and decision-making skills, change agility, and a proven track record working across the broader franchise team, CMO, Medical, Market Access, Sales, Insights & Analytics, AI/Data Science partners, and agency cohorts.

• Directly own the design and execution of an AI-enabled marketing strategy — leveraging machine learning, predictive analytics and next-best-action engines to identify, prioritize and engage the right precision-medicine customers at the right moment.
• Lead the complexity of precision targeting across two biomarker-defined NSCLC populations (ALK+ and BRAF V600E-mutant) aligning brand strategy, diagnostic/testing pathways and HCP engagement so the right patients are identified and reached.
• Set a multi-year strategic vision for the lung portfolio — anticipating shifts in the ALK+ and BRAF V600E competitive landscape, evolving standards of care, and biomarker-testing dynamics, and shaping brand strategy today to protect and grow the franchise over a 3–5-year horizon.
• Partner cross-functionally with the BRAFTOVI + MEKTOVI brand team to drive the BRAF V600E-mutant NSCLC (lung) indication — coordinating lung-specific strategy, promotional review, biomarker-testing initiatives and field execution.
• Connect the patient journey — build the operating model, metrics and feedback loops that connect field sales and marketing execution directly to patients and hold both accountable to shared commercial outcomes.
• Strategize proactively with the Market Access team to anticipate and overcome payer challenges — shaping access strategy, coverage and reimbursement positioning, and value messaging so that appropriate, biomarker-driven patients can be identified and treated without access barriers.
• Elevate what we can say to our customers and when — elevate clarity, credibility and evidence base of our messaging so it lands with impact in an AI-enabled, data-saturated environment.
• Directly accountable for oversight and execution of the in-line lung portfolio and its performance, including quarterly earnings preparation, latest estimates, and operating plan.
• Develop the overall HCP and customer strategy and tactics to support appropriate utilization of the lung portfolio across both biomarker segments, grounded in precision-medicine insight.
• Support the development and implementation of annual tactical plans that drive short- and long-term HCP and patient strategy, based on key customer and data-driven insights.
• Continuously own the measurement and impact of marketing initiatives — using advanced analytics to generate learnings and drive continuous improvement against brand objectives.
• Ensure marketing materials are compelling, compliant and appropriate across all channels, including AI-enabled and omnichannel touchpoints.
• Directly lead and develop a talented team of director- and senior-manager-level marketers to achieve high performance and maximize potential.
• Build a compelling strategic narrative and influence senior leadership — translating market complexity into a clear, well-reasoned point of view, securing alignment and investment, and representing the lung franchise in enterprise strategic-planning forums (OP/LE, brand and portfolio reviews).
• Identify strategic customer insights through collaboration with Medical, Market analytics, AI/data-science, field force and prescribers, and translate them into actionable strategies.
• Conduct all responsibilities in accordance with Company policies, with strong adherence to our Values, including compliance and the responsible use of AI.

• Bachelor's degree and 12+ years of pharmaceutical industry experience required, or Master's degree and 10+ years, or Ph.D./PharmD and 7+ years of experience required.
• Proven experience applying AI-enabled or advanced-analytics approaches to commercial marketing — e.g., machine-learning-driven customer targeting, next-best-action, predictive modeling or omnichannel personalization.
• Track record of connecting commercial initiatives to revenue outcomes — building the metrics, incentives and operating cadence that align teams with commercial and financial performance.
• 5+ years' experience managing or leading marketing colleagues at all levels (Manager to Director), with a commitment to fostering team engagement, culture and people development.
• Demonstrated success with US product launch and lifecycle management preferred.
• Demonstrated experience partnering with Market Access to develop payer, coverage and reimbursement strategy — anticipating access hurdles and shaping value messaging to protect appropriate patient access.
• Advanced strategic-thinking skills — a demonstrated ability to think at the enterprise and franchise level, anticipate market and competitive shifts, make complex trade-off and resource-prioritization decisions, evaluate business opportunities, and build and sell in strategic business cases to senior leadership.
• Excellent communication and presentation skills (oral and written).
• Strong project-management skills with a demonstrated ability to lead large, diverse cross-functional teams.
• Breadth of diverse leadership experiences — the ability to influence and collaborate with peers, coach others, and guide the work of colleagues to create meaningful business impact.
• Demonstrated ability to manage and deliver results on multiple, complex, competing projects in a deadline-oriented environment.

• MBA or other advanced degree highly desirable.
• Prior experience marketing an oncology, precision-medicine or biomarker-driven therapy.
• Working fluency with AI/data-science tools and the ability to partner credibly with analytics and data-science teams to translate models into commercial action.
• Previous in-line US marketing experience preferred.

• Comfort working in a fast-paced environment and making complex decisions quickly.
• Ability to synthesize and analyze complex data, including AI-generated outputs, and understand trends and quantitative relationships.
• Ability to travel domestically and internationally as needed for congresses and customer engagements; expected domestic travel ~20%.
• Ability to work on a computer for extended periods using common applications (Outlook, Excel, PowerPoint) and AI-enabled productivity and analytics tools.

Other Job Details:

Last Date to Apply for Job: September 23rd, 2026

Additional Location Information: New York, NY; Collegeville, PA; Cambridge, MA; Groton, CT; Bothell, WA, Lake Forest, IL; La Jolla, CA

Eligible for Relocation Package: No

#LI-PFE


The annual base salary for this position ranges from $230,900.00 to $384,800.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 25.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.



This role is posted in multiple locations. If you are applying for the role in an secondary job posting location where pay transparency regulations apply, your Talent Advisor will share the local pay information with you during the first interview.




Relocation assistance may be available based on business needs and/or eligibility.




Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.






To learn more about acceptable and prohibited uses of AI during the recruitment process, please review our candidate AI-use guidelines available on Pfizer Careers.


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