Our portfolio (Inactive)

4D Molecular Therapeutics is a gene therapy company with a transformative discovery platform – Therapeutic Vector Evolution – that enables invention of optimized and proprietary AAV vectors, each specifically designed to deliver genes to specific cells and tissues in the body, allowing treatment of diseases with high unmet medical needs.

Ablexis’ AlivaMab™ Mouse technology, a world-class transgenic mouse platform, is being developed to provide the foundation for the efficient discovery and development of the next wave of human therapeutic antibodies to treat human diseases.

Accelerator New York is a leading life science investment vehicle supporting emerging biotechnology research. Accelerator will infuse strategic venture capital, entrepreneurial leadership, and critical product development capabilities into the New York City life science cluster.

Adapsyn applies proprietary algorithms and artificial intelligence to genomic and metabolomic data from microbes to find novel natural product drug candidates. The company has created a turnkey solution to drive the discovery of a diversified portfolio of drugs, thereby expediting the search for medicines that will better treat a wide spectrum of diseases.

AMRA is a medical technology company that analytically transforms MR images into precise body composition measurements using a cloud-based, computer aided service. These highly accurate measurements aid metabolic research and drug development in the challenging areas of obesity and its co-morbidities.

Anjarium Biosciences, strives to create and deliver solutions for patients beyond what current gene therapy platforms address today. Anjarium is developing a new generation of genetic medicines to overcome the greatest challenges facing the field, notably immunogenicity, payload capacity, individualized multiple dosing, targeted delivery and scaled manufacturing.

Aquinox is developing novel small molecule therapeutics for the treatment of cancer and inflammatory disease.

Arkuda has discovered new and evolving insights about the importance of progranulin and granulins in regulating lysosomal health in frontotemporal dementia and is driving the discovery of exciting new medicines for FTD-GRN and other neurodegenerative diseases.

Aureon used systems pathology to develop predictive clinical tests for cancer care, as well as to enable bio-pharmaceutical research and development. 

Avid Radiopharmaceuticals, Inc. was a product-focused molecular imaging company pioneering development of radiopharmaceuticals for imaging disease pathology.

Aviir was developing cutting-edge, convenient molecular diagnostic tests to enable accurate diagnosis and prognosis of cardiovascular disease.

BioAtla develops novel monoclonal antibody and cell-based immunotherapies with improved therapeutic index for the treatment of cancer.

BioNTech leverages its deep immunology expertise and experience to develop and optimize mRNA therapeutics for serious diseases such as cancer, COVID-19, malaria and tuberculosis.

Blade Therapeutics is advancing a differentiated pipeline of oral, small-molecule therapies that include a non-competitive autotaxin inhibitor and inhibitors of dimeric calpains for the potential treatment of lung, liver and cardiac fibrosis or neurodegenerative diseases. Since the company’s founding in 2015, Blade has used a combination of in-house drug research and selective in-licensing to build a risk-diversified pipeline.

BlueLight Therapeutics was a biotechnology company that used novel structure-function-based approach to develop new therapeutic molecules against challenging drug targets to treat a wide range of serious diseases.

Bolt is a clinical-stage biotechnology company developing its Immune-Stimulating Antibody Conjugate (ISAC) platform technology to harness the power of the innate immune system to treat cancer.

Clovis Oncology is a biopharmaceutical company focused on acquiring, developing and commercializing innovative anti-cancer agents. Clovis intends to target development programs at specific subsets of cancer populations, and will simultaneously develop diagnostic tools that direct a compound in development to the population that is most likely to benefit from its use.

Complexa was a clinical stage biopharmaceutical company focused on transforming the treatment of fibrosis and inflammation-associated orphan diseases.

Cortexyme was developing therapeutics based on a new theory of the cause of Alzheimer's and other degenerative disorders.

Cydan was an orphan drug accelerator that worked to identify and de-risk rare disease programs with therapeutic and commercial potential. 

CytomX Therapeutics is a clinical-stage biopharmaceutical company with a deep and differentiated oncology pipeline of investigational Probody therapeutics.

DIR Technologies was a developer and provider of first-in-industry inspection solutions for the pharmaceutical packaging and manufacturing industries.

DVS Sciences Inc. was an analytical equipment and reagents development company that produced and marketed the CyTOF®, a high throughput mass cytometer for individual cell analysis based on a novel elemental mass-spectrometry detection technology, and the MAXPAR® system of novel reagents related to massively multi-parametric assays.

eFFECTOR is a clinical stage biopharmaceutical company pioneering the discovery and development of selective translation regulators as a new class of small molecule drugs for treating cancer.

Eiger is a clinical-stage biopharmaceutical company committed to developing and commercializing novel products for the treatment of Orphan diseases.

Entelos was developing computer-based disease-simulation models, called PhysioLabs that enable in-silico drug discovery and development.

Epic Sciences is focused on developing novel diagnostics to improve and personalize the treatment and management of cancer. Epic was founded on a powerful platform to identify and characterize rare cells, including circulating tumor cells (CTCs).

Evolution Benefits (EB) offered innovative, integrated products for the employee benefits market.

Flexion Therapeutics is a specialty pharmaceutical company focused on the development and commercialization of novel, local therapies for the treatment of patients with musculoskeletal conditions, beginning with OA, a type of degenerative arthritis.

G-Con designs and manufactures “PODs”, portable, self-contained cGMP facility modules that offer a cost-effective and flexible alternative to large, highly capitalized pharmaceutical manufacturing facilities with fixed equipment and limited flexibility.

Genomic Health is focused on the development and commercialization of genomic-based clinical diagnostic tests for cancer that allow physicians and patients to make individualized treatment decisions. In 2004, they launched their first test under the brand name Oncotype DX® for early stage breast cancer.

HandyLab develops and manufactures small, low-cost nucleic acid and protein-based analysis systems based on its patented and proprietary microfluidic, miniaturized real time PCR, and nucleic acid extraction technologies. The company's lead product, Jaguar, combines rapid nucleic acid sample preparation with microfluidic PCR for nucleic acid detection. 

HD Biosciences (HDB) was a Shanghai China based clinical research organization (CRO) that provides drug discovery contract research services, with an emphasis on high value biology screening. 

Imara was developing inhibitors for sickle cell disease and other hemoglobinopathies. 

Ixchelsis Limited was a UK based biotechnology developing oxytocin receptor antagonists with the potential to treat benign prostatic hypertrophy and prostate cancer.

Jnana Therapeutics is building the first small molecule drug discovery platform dedicated to SLC transporters, an ancient membrane protein family thought to be relevant in a wide range of diseases. Jnana’s proprietary chemistry and biology platform allows the company to rapidly and comprehensively address therapeutic targets across the SLC family, with an initial focus on immuno-oncology, inflammatory disorders, and neurological diseases.

Kymera Therapeutics is pioneering a transformative new approach to treating previously untreatable diseases by advancing the field of targeted protein degradation, accessing the body’s innate protein recycling machinery to degrade dysregulated, disease-causing proteins.  Using its protein degradation platform, the company is building a therapeutic pipeline in oncology and immunology.

Lodo used its genome-based, culture-independent platform combines DNA sequencing and bioinformatics to discover, synthesize, and characterize small-molecule therapeutics from natural microbial sources present in soil samples and the human microbiome.

M2S is a pioneer and leader in imaging and data management technology. They were the first to develop and market 3-D imaging technology to vascular surgeons. 

Mangolia Neurosciences was a drug discovery and development company focused on the creation of a novel class of neuroprotective medicines.

Mersana Therapeutics is a clinical-stage biotechnology company with highly differentiated and proprietary antibody drug conjugate (ADC) platforms that allow for significantly higher drug loads, with the potential to provide greater efficacy while simultaneously increasing tolerability.

Merus is a clinical-stage immuno-oncology company developing innovative full-length human bispecific antibody therapeutics.

Metabomed was a drug discovery company in the field of cancer metabolism. 

Mirna Therapeutics focused on research and development of miRNA-directed human oncology therapies.

Mitokinin is developing small molecule therapeutics targeting PINK1, a master regulator of mitochondrial quality control genetically linked to Parkinson’s disease. By selectively amplifying active-form PINK1 activity, Mitokinin is addressing cellular pathologies underlying Parkinson’s disease and ultimately slow or halt the progression of the disease.

Morphic Therapeutic is engaged in the discovery and development of a new generation of oral integrin drugs.

NeuMoDx is developing a next generation testing platform for the in vitro molecular diagnostic (MDx) market.

Neuronetics is focused on developing non-invasive therapies for psychiatric and neurological disorders using MRI-strength magnetic field pulses.

NexImmune is developing novel immune-therapeutics for a variety of cancers and other diseases based on the proprietary Artificial IMmune (AIMTM) technology.

NextCure is discovering and developing first-in-class immunotherapy-based biologics for cancer and other diseases, building upon the work of its scientific founder, Dr. Lieping Chen.

Nodality, Inc. is an emerging biotechnology company focused on patient-specific classification of disease. Nodality’s technology profiles signaling networks in single cells by multiparametric phospho-flow cytometry.  The technology can address many aspects of drug development with a primary focus on acute myeloblastic leukemia (AML) and chronic lymphocytic leukemia (CLL).

Therapeutic oncology device that delivers Tumor Treating Fields (TTFields) to tumor sites through the skin. The TTfields are low intensity, alternating electric fields that cause physical disruption of dividing (cancerous) cells, but leave normal cells largely unaffected.

Petra Pharma was developing novel small molecules for the treatment of cancer and metabolic diseases to target these cellular processes to therapeutically impact human health.

Pyxis Oncology is building a differentiated portfolio of biologics, including antibody-drug conjugates (ADCs) and immunotherapies, to improve the lives of patients with difficult-to-treat cancers.

Quartet is an early-stage biopharmaceutical company developing drugs against a novel pain target, Tetrahydrobiopterin (BH4), an essential co-factor in the production of certain neurotransmitters.

RaNA was developing a new class of therapeutics made of messenger RNA (mRNA), designed to enable in vivo production of intracellular, membrane-associated and secreted proteins.

Rhythm is a biopharmaceutical company developing peptide therapeutics that address unmet needs in metabolic diseases.

Second Genome has built a novel microbiome technology platform, resulting in a pipeline of drug discovery programs, including several microbiome-derived proteins, peptides and metabolites, with applications across gastrointestinal disease, immuno-oncology, inflammation and metabolic diseases. 

Simcha Therapeutics is an early-stage biopharmaceutical company with a focus on developing next generation cytokine immunotherapies to trigger the immune system to fight disease, particularly cancers.

SpringWorks Therapeutics is a clinical-stage biopharmaceutical company that applies a precision medicine approach to acquiring, developing and commercializing life-changing medicines for underserved patient populations suffering from severe rare diseases and cancer. The company launched in 2017 with a portfolio of clinically validated therapies in-licensed from Pfizer.

superDimension has developed the inReach™ system in answer to one of the most critical needs in the field of pulmonology: minimally invasive access to peripheral lung locations.

Provider of pharmaceutical supply chain security solutions to pharmaceutical companies and their trading partners seeking to enhance product integrity and supply chain efficiency.

System1 employs phenotypic screening to discover novel drugs for complex neurological and psychiatric diseases for which current discovery techniques have proved least successful.

TetraLogic was a biopharmaceutical company developing novel, targeted drugs to treat cancer.

Therachon was a clinical-stage global biotechnology company focused on developing medicines for rare diseases with significant unmet need.

Triplet Therapeutics was a biotechnology company harnessing human genetics to develop treatments for repeat expansion disorders at their source.

VectivBio is a spin out of Therachon (acquired by Pfizer in 2019), that will focus on conditions caused by well understood molecular alterations that can be targeted with transformational therapeutics.   The company was acquired in 2023 by Ironwood Pharmaceuticals.

Vtesse, Inc. was a rare disease company dedicated to developing drugs for patients suffering from diseases that are underserved.

Yumanity Therapeutics was a therapeutics company focused on Parkinson’s disease, Alzheimer’s disease and ALS.

Ziarco is a clinical stage biotechnology company developing innovative therapeutics targeting inflammatory skin diseases.