Principal Scientist
- United States - Washington – Bothell
A Principal Scientist (R5) position is available in the Downstream Process Development group within Bioprocess R&D. The successful candidate will have strong laboratory research experience and a desire to remain in a hands-on, laboratory-focused role.
This position will be part of a multidisciplinary team of scientists across multiple sites focused on the development and optimization of recovery and purification processes for recombinant proteins expressed in mammalian cell culture, supporting early- and late-phase clinical programs. The Principal Scientist will independently develop robust, efficient, and scalable downstream strategies to improve process performance, enable successful technology transfer, and provide scientific leadership within project teams.
ROLE RESPONSIBILITIES
· Design, execute, and independently lead small-scale downstream process development studies, with support for pilot-scale and manufacturing purification activities.
· Analyze experimental data to develop, test, and refine hypotheses that improve the fundamental understanding of recovery and purification processes.
· Contribute to and help lead process characterization, validation strategies, Quality by Design (QbD) approaches, and regulatory filings.
· Author technical reports, present scientific results to cross-functional teams and management, and publish externally as appropriate.
· Serve as a downstream process development technical resource within project teams and contribute to cross-functional decision-making.
· Identify and implement opportunities for operational efficiency and continuous improvement across Bioprocess R&D workflows.
· Support change initiatives related to business infrastructure, platforms, and technologies to enable pipeline, legacy, and innovation programs.
· Provide technical guidance and mentoring to colleagues as appropriate.
EDUCATION
· Bachelor’s degree with 11+ years of relevant experience, or
· Master’s degree with 8+ years of relevant experience, or
· PhD with 3+ years of relevant experience
Degrees should be in a biological or engineering discipline, e.g., Biotechnology, Chemistry/Biochemistry, Chemical or Biochemical Engineering, or equivalent.
REQUIRED EXPERIENCE/SKILLS
· Hands-on experience in recombinant protein downstream process development, technology transfer, and/or bioprocess manufacturing.
· Strong understanding of protein chemistry and protein analytics, with demonstrated ability to apply current scientific literature.
· Proven ability to independently drive experimental strategy, deliver results, and contribute innovative solutions within project teams.
· Demonstrated ability to work in ambiguous technical situations, make data-driven recommendations, and manage project priorities.
· Highly organized, self-motivated, and capable of working both independently and collaboratively in a matrix environment.
· Excellent written and verbal communication skills, including technical documentation and presentations.
· Strong analytical, data interpretation, and computer skills.
· Ability to manage workload effectively and contribute to planning of people, technology, and project resources.
DESIRABLE EXPERIENCE/SKILLS
· Experience with recovery and purification of recombinant proteins from mammalian and microbial or yeast expression systems.
· Experience transferring biologics processes to pilot-scale or commercial manufacturing, including familiarity with data acquisition and process control systems.
· Experience supporting late-stage development, process validation, and commercialization activities.
· Working knowledge of statistical experimental design and data analysis.
· Broad understanding of the biologics drug development process and requirements for advancing candidates through clinical development.
PHYSICAL/MENTAL REQUIREMENTS
Work will be performed in a typical development laboratory environment and in GLP/GMP manufacturing facilities including the operations areas of pilot plants.
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Occasional weekend work and travel to support clinical manufacturing.
Work Location Assignment: On Premise






Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.
U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

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