Scientist, Oncology Discovery (Multi-Specific Antibody Therapeutics)
- United States - California - San Diego
Use Your Power for Purpose
At Pfizer, our purpose is to deliver breakthroughs that change patients’ lives. Research and Development plays a critical role in turning cutting-edge science into innovative medicines. Within Pfizer Oncology, we are advancing next‑generation therapeutics to address areas of high unmet medical need for the benefit of patients globally.
What You Will Achieve
As a Scientist in the Discovery Technologies department, you will contribute directly to early‑stage programs focused on discovery of next generation biologics for oncology. Your work will generate high-impact functional screening data that guides antibody discovery decisions, informs lead molecule selection, and enables portfolio progression of transformative therapeutics. In this role you will:
Design, develop, and execute high-throughput cell‑based functional assays in support of multi‑specific antibody and T cell engager discovery programs
Perform assays measuring target engagement, cell binding,T cell-mediated cytotoxicity of tumor cells, and T cell activation in the presence of antibody therapeutics; with flow cytometry, luminescence, NanoBRET, and HTRF-based readouts
Culture and maintain cancer cell lines and primary human T cells in vitro
Generate and engineer cell lines using molecular cloning, transfection, lentivirus production, and transduction
Implement and support high‑throughput and semi‑automated assay workflows, including use of Echo liquid handling systems and 384-well plate assay formats
Analyze, interpret, and clearly communicate experimental data to project teams
Effectively manage, curate, and structure experimental data to maintain high-quality documentation in electronic lab notebooks and enable integration with an AI-ready environment
Collaborate effectively within cross‑functional teams spanning tumor biology, protein engineering, automation, and data sciences
Here Is What You Need (Minimum Requirements)
BS or MS in Biology, Molecular Biology, Cell Biology, Biochemistry, Immunology, or a related discipline
BA/BS with at least 6 years of experience or MBA/MS with at least 4 years of experience working with antibody-based therapeutics in biotechnology or pharmaceutical settings.
Hands‑on experience with cell‑based functional assays, particularly those assessing immune cell function (e.g., T cell cytotoxicity assays)
Demonstrated proficiency in mammalian cell culture, including cancer cell lines and primary immune cells
Experience executing assays in high‑throughput or semi‑automated formats, including familiarity with laboratory automation and 384-well plate assay formats
Strong data analysis, organization, and documentation skills
Excellent written and verbal communication skills and the ability to work productively in cross‑functional teams
Ability to adapt quickly in a fast‑paced, discovery‑driven research environment
Bonus Points If You Have (Preferred Requirements)
Experience with molecular biology techniques, including cloning, transfection, lentivirus production, and cell line engineering
Familiarity with biochemistry/biophysicalanalytical techniques used to characterize antibodies and other biologic therapeutics (SPR, HPLC, Mass spectrometry)
Experience with Genedata platforms (Biologics, Screener) or similar
PHYSICAL/MENTAL REQUIREMENTS
Laboratory work requiring standing or sitting for extended periods
Ability to work with biological samples and standard laboratory equipment
Other Job Details:
Last Date to Apply for Job: June 1st, 2026.
Locations: USA - CA - San Diego (Torrey Heights)
NOT eligible for Relocation Package
This position is on premises and requires working onsite.
Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.
U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Pfizer endeavors to make www.pfizer.com/careers accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email disabilityrecruitment@pfizer.com. This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned.
Breakthroughs that change patients’ lives
Research confirms what intuition tells us: that purpose-driven companies perform better, are more innovative, attract and retain the best people, and know how to unleash the power of those people. Pfizer’s purpose—Breakthroughs that change patients' lives—fuels everything we do and reflects our passion for building on our legacy as one of the greatest contributors of good to the world.
Each word in our purpose has meaning and reflects the value we strive to bring to patients and society:
“Breakthroughs” - These are the innovations, scientific and commercial, that we seek to deliver every day. All colleagues, regardless of role, level or location, strive for breakthroughs every day.
“Change” - We want to do more than simply improve patients’ medical conditions; we want to dramatically change their lives for the better.
“Patients’ lives” - We consider not only patients, but everyone they touch—including their families, caregivers, and friends—and everything they love to do. It’s an intentionally holistic view.
Our purpose ensures that patients remain at the center of all we do. We live our purpose by sourcing the best science in the world; partnering with others in the healthcare system to improve access to our medicines; using digital technologies to enhance our drug discovery and development, as well as patient outcomes; and leading the conversation to advocate for pro-innovation/pro-patient policies.
Every decision we make and every action we take is done with the patient in mind—and to nurture an environment where breakthroughs can thrive.
Our Values
To fully realize Pfizer’s purpose, we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.
The “how” is represented by four simple, powerful values—courage, excellence, equity, and joy—that define our company and our culture.
Courage: Breakthroughs start by challenging convention, especially in the face of uncertainty or adversity. This happens when we think big, speak up, and are decisive.
Excellence: We can only change patients’ lives when we perform at our best together. This happens when we focus on what matters, agree who does what, and measure our outcomes.
Equity: We believe that every person deserves to be seen, heard, and cared for. This happens when we are inclusive, act with integrity, and reduce healthcare disparities.
Joy: We give ourselves to our work, but it also gives to us. We find joy when we take pride, recognize one another, and have fun.
Pfizer Research & Development
Pfizer Research & Development serves as the beating heart of Pfizer's trailblazing product pipeline, the essence of our mission to bring life-changing medicines to the world.
With an unwavering commitment to innovation, we use a multidisciplinary approach that blends scientific expertise, cutting-edge technologies, and strategic collaborations, igniting a powerful engine that propels groundbreaking discoveries into life-saving treatments for patients in need.
Through our relentless pursuit of progress, we envision a future where cutting-edge medicines pave the way to healthier, happier lives worldwide.
Benefits at Pfizer
Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues. Our Pay for Performance Philosophy and Practices reward colleagues based on the contributions they make to our business.
Our Competitive Benefits Programs help our colleagues by:
- Promoting Health and Wellness to help colleagues maintain and improve their physical and mental wellbeing. Pfizer offerings include health and disability insurance, preventative health programs, medical screenings, free or reduced-cost vaccinations, discounts on Pfizer products, mental health support, nutrition and fitness counseling and more.
- Strengthening Colleagues’ Financial Security by providing company contributions to retirement plans, life insurance and financial planning education to help colleagues achieve their financial goals.
- Providing Benefits and Time off for the Moments that Matter to ensure Pfizer colleagues have the time away from the office to recharge, recover and return to work as the best version of themselves. Vacation, Holiday time and Sick time are just the beginning, with a 12 week parental leave policy for both parents of a new born, 10 day of caregiver leave for those times when your family needs you whether it’s a child, spouse or parent, bereavement leave, and additional country-specific programs.
- And so much more, depending on your country and site, Pfizer offers childcare facilities or discount programs, on-site health and/or fitness centers, movement and mindfulness solutions, “Log in for your Day” work flexibility and so much more.
For U.S. based jobs, view an overview of Pfizer’s U.S. benefits program (opens in a new window)