Postdoctoral Fellow, Tissue Proteomics

Why Patients Need You

At Pfizer we deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.

What You Will Achieve

The Liquid Chromatography–Mass Spectrometry (LCMS) Biomarkers/Biomeasures team plays a vital role in this mission through the quantification of therapeutic targets utilizing state-of-the-art proteomics techniques. We are seeking a highly motivated Postdoctoral Fellow with experience in mass spectrometry-based proteomics, bioinformatics or machine learning interested in continuing their scientific development in a highly dynamic environment here at Pfizer.

The successful candidate will be exposed to the latest mass spectrometry (MS) infrastructure. They will have an opportunity to contribute to an exciting project impacting drug discovery. Come and join our great and diverse team that includes other postdoctoral fellows.

In this role, the Postdoctoral Fellow will generate comprehensive proteome-wide knowledge of protein targets in tissues as proteome maps and will drive forward the development of bioinformatic methods that integrate different proteomics data modalities. This project is expected to have impact on our approach to target feasibility assessment and will lead to strong publications.

How You Will Achieve It

In your new role, you will leverage advanced mass spectrometry to generate data to combine with bioinformatics approaches. You will also work on the MS-based proteomics outputs generated from variety of search engines to create a deeper understanding of protein expression in tissue organ-specific data repositories that would accelerate biomeasure assay development.

You will also establish research collaborations, present at conferences, and lead or contribute to publications.

Qualifications

Must-Have

• Ph.D. in Proteomics, Biological Sciences, Bioinformatics, Statistics, Analytical Chemistry or a related field with experience in one or more of the following areas as demonstrated through at least one first-author publication: Computational biology, Bioinformatics, Proteomics, Machine Learning.
• No more than 2 years of post-degree experience.
• Willingness to make a minimum 2-year commitment.
• Experience with label-free quantification, data dependent or independent acquisitions (DDA, DIA) methods
• Previous experience with large scale proteomics datasets
• Proficiency in programming languages such as R or Python
• Experience with proteomics search engines and databases
• Experience with advanced proteomics instruments such as Bruker TimsTOF and/or Thermo Orbitraps 
• Strong oral and written communication skills and the ability to work independently and as part of a team with a track record of scientific publications in peer-reviewed journals.

Nice-to-Have

• Deep understanding of biological systems, including pathway regulation, post-translational modification, molecular and cell biology, etc.
• Familiarity with how machine learning can be applied to MS-derived proteomics data 
• Comfortable learning new API's and tools as needed. Experience working in cloud-based and mixed computing environment using proteomics data.
• Worked on Multi-omics Datasets

Other Job Details:

• Must have work authorization in the US
• Work Location Assignment: On Premise.

The annual base salary for this position ranges from $60,900.00 to $101,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Research and Development