Senior Director, HTA, Value & Evidence (HV&E) – Lung Cancer & Precision Medicine

As a leading biopharmaceutical company, Pfizer is dedicated to the discovery and delivery of high value therapies across a variety of disease areas. It is our mission to bring innovative medicines to patients that significantly improve their lives, and our priority is to ensure patients have access to these medicines.

The Health Technology Assessment (HTA), Value & Evidence (HV&E) team is responsible for ensuring patients have affordable, timely access to medicines and vaccines by advancing innovative value and evidence solutions to inform healthcare decision-making.

The Senior Director, HTA, Value & Evidence (HV&E) – Lung Cancer & Precision Medicine role directly impacts the ability to achieve business objectives on a global basis by providing strategic guidance and robust evidence development relevant to defend the value proposition of Ph3 compounds in development in support of Pfizer’s thoracic cancer franchise. The Senior Director will be responsible for independently leading the evidence generation strategy at a Global level, including execution and dissemination of technical deliverables that support the value of antibody-drug conjugate (ADC) candidate SGN-PDL1V (PF-08046054) and the broader thoracic cancer franchise. The Senior Director will work closely with the countries to support their evidence needs for HTA submissions and price negotiations. For PF-08046054, the Senior Director will be responsible for developing launch deliverables to key internal and external stakeholders. This role will be predominantly focused on supporting the Global business. In addition to PF-08046054 as the core responsibility, the Senior Director will also have accountability for supporting and driving access evidence of Pfizer’s thoracic cancer franchise, in partnership with the HV&E Team Lead.

The Senior Director, HTA, Value & Evidence (HV&E) – Lung Cancer & Precision Medicine will function with a one-GAV mindset, promoting behaviors that exemplify Pfizer’s values (Courage, Excellence, Equity and Joy). This position will require working in a closely aligned fashion with various cross-functional team members (global access strategy, medical, US HV&E, medical evidence generation, and commercial) to ensure there is a single and coordinated view on strategy and evidence delivery to support PF-08046054. This position reports to the Senior Director HV&E Team Lead - Lung Cancer & Precision Medicine.

RESPONSIBILITIES:

• Lead the development of Health Economics & Outcomes Research (HEOR) strategy to support the value of PF-08046054 and the thoracic cancer franchise in close partnership with the cross-functional matrix team
• Lead the design and execution of Global HEOR studies and projects (including non-interventional studies, registries, burden of illness studies, economic models, epidemiologic studies etc.)  
• Incorporate humanistic and economic endpoints into clinical trials across all phases of product development to build comprehensive trial-based evidence in line with overall medical strategy for the assets and to ensure global reimbursement and access requirements
• Provide strategic input in the selection of relevant patient population and comparators within clinical trials to enable successful negotiations, reimbursement, and appropriate patient access with global payer and regulatory decision makers
• Lead the timely development of launch and post launch deliverables including global value dossiers, access evidence plans, value and evidence strategies, economic models, and innovative tools to successfully support global launches
• Partner with the countries to understand their evidence needs and lead the coordination of input from local country/regional teams on global evidence generation to ensure that the input is appropriately incorporated into key HTA deliverables (economic models, global dossiers, RWE)
• Communicate and educate internal and external stakeholders on PF-08046054 RWE, develop RWE narratives and provide advice on how to utilize RWE/RWD
• Develop strategic partnerships and research collaborations with key external experts, healthcare policy makers, payers, and various academic and community settings to support asset strategies
• Provide strategic guidance and content guidance in reimbursement (re)negotiations for PF-08046054
• Lead the development of appropriate data dissemination plans and communicate evidence generated via publications and conference presentations
• Partner with internal stakeholders (e.g. medical, access strategy, payer marketing) to ensure appropriate customer facing dissemination of HEOR materials per FDA guidance and internal SOPs

BASIC QUALIFICATIONS

Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

• Master’s degree in public health, health economics or allied discipline with 10+ years’ experience in pharmaceutical industry, HEOR consulting, HEOR academic roles, or related industry; 7+ years of experience required with Doctorate degree (PharmD. PhD, DrPH)
• Deep expertise in HEOR technical knowledge, policy impact, and extensive experience in planning and executing on HEOR strategy/alignment (RWE, PROs and economic modelling)
• High-level leadership, ability to develop and drive TA, Product, organizational strategy, and mentor future leaders
• Demonstrated ability to manage multiple projects involving complex processes, significant budget, competing deadlines and rapidly shifting priorities
• Wide professional networks and established track record of working with external KOLs
• Ability to influence key members of scientific and commercial teams, constructively and strategically, with minimal conflicts
• Excellent oral and written English communication skills
• Strong collaborator and team-player
• Demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact

PREFFERED QUALIFICATIONS

• Experience in non-small cell lung cancer from an HEOR perspective
• Expertise in technical and methodological aspects of RWE such as retrospective and prospective observational study design and implementation in US and other countries (real world evidence)
• In depth understanding of HEOR methods, including advanced modelling techniques, health-related quality of life, other PRO measures and macroeconomics
• Experience in HTA submissions and managing country/regional matrix partners

Other Job Details:

• Last Date to Apply for Job: January 09th, 2026.
• Ability to work across all US time zones
• Tight deadlines and shifting priorities are characteristic of this role
• Ability to travel domestically and internationally based on business needs
• NOT eligible for Relocation Package
• This position is hybrid and requires working onsite 2 to 3 days per week
• Eligible for employee referral bonus

#LI-PFE

The annual base salary for this position ranges from $204,700.00 to $341,100.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 22.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

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