Principal Scientist
- United States - Massachusetts - Cambridge
Job Responsibilities
The Pharmacokinetics, Dynamics and Metabolism (PDM) department in Pfizer Inc. is looking to identify a project representative who will serve as an integral project team member representing PDM on small molecule (including protein degraders, molecular glues, etc.) and protein therapeutics (e.g., peptides, mAbs, mAbs-conjugates, fusion proteins, etc.) research and development programs. In this role, you will be expected to ensure effective integration of absorption, distribution, metabolism & excretion (ADME) characterization and optimization, bioanalysis, translational pharmacokinetics/pharmacodynamics (PK/PD), and immunogenicity strategies into research objectives to facilitate the advancement of novel chemical and biological entities. While doing so, you will also work closely in a matrix-team environment with ADME scientists from multiple (small molecule and biologics) modalities to ensure the execution of appropriate experimental plans and data interpretation to provide strategic directions to discovery project teams.
As a PDM point-of-contact for the discovery project teams, you will utilize ADME knowledge gathered from disposition studies to influence all stages of the discovery phase including hit-to-lead, lead development and candidate optimization. You will also interphase with pharmacologists, toxicologists, PK/PD modelers and clinical pharmacokineticists to develop translational pharmacology plans, human pharmacokinetics, dose and therapeutic margin projections for clinical candidates. In the preclinical development phase, you will interphase with asset development teams and contribute to the design and execution of regulatory toxicology studies, prepare the regulatory dossier with relevant ADME information, respond to regulatory queries, and support early clinical human pharmacokinetics, safety, and tolerability studies. Central to this role is an ability to propose practical solutions to address complex ADME and pharmacology hurdles as they arise in early discovery, and an ability to grasp multiple drug disposition concepts as applicable to both small and large molecule modalities.
How You will Achieve It
- Application of functional/technical knowledge to design appropriate in vitro and in vivo disposition studies in collaboration with the PDM matrix team to explore ADME issues in small and large molecule drug discovery programs
- Provide strategic directions to multidisciplinary project teams through interpretation and effective communication of experimental ADME data
- Ensure effective use of internal and external PDM resources to deliver project milestones
- Advance scientific and technology (including AI strategies) innovation and excellence that translate to portfolio impact
Minimum Requirements
- PhD level education with post-doctoral and/or some industry experience (or BS/MS with 10–14 years of prior experience) with graduate research focus on topics related to drug/xenobiotic disposition within small or large molecule realm, medicinal chemistry, physical organic chemistry/computational ADME, biochemistry, or pharmacokinetics (quantitative pharmacodynamics modeling), with a strong record of scientific achievements (e.g., peer-reviewed publications)
- Excellent interpersonal, written/verbal communication and presentation skills, with an ability to collaborate effectively within a multidisciplinary team environment
Preferred Skills
- Demonstrated expertise in one or more areas of drug disposition science (small and/or large molecules), drug metabolism/enzymology, medicinal chemistry, protein analytics, modeling and simulation etc. with an emphasis on innovative problem-solving approaches to scientific problems
- Mechanistic modeling/simulation of pharmacokinetics and pharmacodynamics data
- Broad understanding of pharmacokinetics and drug (small molecules and biologics) concepts
- Skills in coding and/or innovative use of AI approaches in biopharmaceutical research
PHYSICAL/MENTAL REQUIREMENTS
Sitting, Standing, Walking, ability to perform mathematical calculations and ability to perform complex data analysis.
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Travel and adhere to safe work practices
Relocation support available
Work Location Assignment: Hybrid
The annual base salary for this position ranges from $106,000.00 to $171,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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Breakthroughs that change patients’ lives
Research confirms what intuition tells us: that purpose-driven companies perform better, are more innovative, attract and retain the best people, and know how to unleash the power of those people. Pfizer’s purpose—Breakthroughs that change patients' lives—fuels everything we do and reflects our passion for building on our legacy as one of the greatest contributors of good to the world.
Each word in our purpose has meaning and reflects the value we strive to bring to patients and society:
“Breakthroughs” - These are the innovations, scientific and commercial, that we seek to deliver every day. All colleagues, regardless of role, level or location, strive for breakthroughs every day.
“Change” - We want to do more than simply improve patients’ medical conditions; we want to dramatically change their lives for the better.
“Patients’ lives” - We consider not only patients, but everyone they touch—including their families, caregivers, and friends—and everything they love to do. It’s an intentionally holistic view.
Our purpose ensures that patients remain at the center of all we do. We live our purpose by sourcing the best science in the world; partnering with others in the healthcare system to improve access to our medicines; using digital technologies to enhance our drug discovery and development, as well as patient outcomes; and leading the conversation to advocate for pro-innovation/pro-patient policies.
Every decision we make and every action we take is done with the patient in mind—and to nurture an environment where breakthroughs can thrive.
Our Values
To fully realize Pfizer’s purpose, we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.
The “how” is represented by four simple, powerful values—courage, excellence, equity, and joy—that define our company and our culture.
Courage: Breakthroughs start by challenging convention, especially in the face of uncertainty or adversity. This happens when we think big, speak up, and are decisive.
Excellence: We can only change patients’ lives when we perform at our best together. This happens when we focus on what matters, agree who does what, and measure our outcomes.
Equity: We believe that every person deserves to be seen, heard, and cared for. This happens when we are inclusive, act with integrity, and reduce healthcare disparities.
Joy: We give ourselves to our work, but it also gives to us. We find joy when we take pride, recognize one another, and have fun.
Pfizer Research & Development
Pfizer Research & Development serves as the beating heart of Pfizer's trailblazing product pipeline, the essence of our mission to bring life-changing medicines to the world.
With an unwavering commitment to innovation, we use a multidisciplinary approach that blends scientific expertise, cutting-edge technologies, and strategic collaborations, igniting a powerful engine that propels groundbreaking discoveries into life-saving treatments for patients in need.
Through our relentless pursuit of progress, we envision a future where cutting-edge medicines pave the way to healthier, happier lives worldwide.
Benefits at Pfizer
Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues. Our Pay for Performance Philosophy and Practices reward colleagues based on the contributions they make to our business.
Our Competitive Benefits Programs help our colleagues by:
- Promoting Health and Wellness to help colleagues maintain and improve their physical and mental wellbeing. Pfizer offerings include health and disability insurance, preventative health programs, medical screenings, free or reduced-cost vaccinations, discounts on Pfizer products, mental health support, nutrition and fitness counseling and more.
- Strengthening Colleagues’ Financial Security by providing company contributions to retirement plans, life insurance and financial planning education to help colleagues achieve their financial goals.
- Providing Benefits and Time off for the Moments that Matter to ensure Pfizer colleagues have the time away from the office to recharge, recover and return to work as the best version of themselves. Vacation, Holiday time and Sick time are just the beginning, with a 12 week parental leave policy for both parents of a new born, 10 day of caregiver leave for those times when your family needs you whether it’s a child, spouse or parent, bereavement leave, and additional country-specific programs.
- And so much more, depending on your country and site, Pfizer offers childcare facilities or discount programs, on-site health and/or fitness centers, movement and mindfulness solutions, “Log in for your Day” work flexibility and so much more.
For U.S. based jobs, view an overview of Pfizer’s U.S. benefits program (opens in a new window)