Inflammation is a critical response to potential danger signals and damage in organs in our body. But with autoimmune diseases such as rheumatoid arthritis, lupus, ulcerative colitis, Crohn’s disease and many others, our own immune system turns against our organs. These painful and debilitating conditions take an immense toll on people’s quality of life and many of these diseases are poorly managed by existing treatments that provide only symptomatic relief.
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Research
Inflammation is a critical response to potential danger signals and damage in organs in our body.
Iain Kilty: What We’re Working on
For decades, doctors relied on steroids to suppress immune response. Though an important option, steroids come with many potentially harmful side effects. Fortunately, science has continued to advance, and today we have the opportunity to transform the management of inflammatory diseases with new classes of therapies that target other key proteins and pathways in the body.
As science evolves beyond broad immunosuppression and into more selective agents, patients living with autoimmune and inflammatory disease have new hope.
As science evolves beyond broad immunosuppression and into more selective agents, patients living with autoimmune and inflammatory disease have new hope. Pfizer scientists operate with a sense of urgency, focused on three areas with the greatest unmet need:
Rheumatology Investigating therapies for rheumatoid arthritis and lupus
Gastroenterology Looking at the next wave of medicines in ulcerative colitis, Crohn’s disease and nonalcoholic steatohepatitis (NASH)
Medical Dermatology Focusing on the next generation of medicines for atopic dermatitis, psoriasis, vitiligo and alopecia areata
Innovation in I&I will remain focused on enabling patients to thrive in remission and to attain cures. It is believed that in the longer term, this will be achieved by evolving the treatment paradigm in inflammation beyond broad immunosuppression. In the clinic, more selective inhibition of pro-inflammatory adaptive pathways is being targeted to deliver transformational induction and maintenance of remission with lower safety risks. Emerging approaches are aimed at promoting restoration of the immune system and tissue health to deliver cures.
Emerging approaches are aimed at promoting restoration of the immune system and tissue health to deliver cures.
Precision medicine is embedded in all of our investigational programs in Inflammation and Immunology, where we seek to better understand the underlying disease biology and identify the group of patients who will respond best to certain treatments. Pfizer sees particular promise in combination therapies to reduce remission rates.
Technologies/Approach
JAK pathwayOur janus kinase (JAK) inhibitor programs are at the heart of our R&D efforts in a number of autoimmune diseases in addition to rheumatoid arthritis. We’re advancing our leading science on the JAK pathway to develop tailored therapies for lupus, psoriasis, ulcerative colitis and alopecia areata – all areas in which we have ongoing clinical trials.
Immune ToleranceActivation of the immune system by self-antigens is the basis of every autoimmune disease. Immunological tolerance is the term describing a host of normal physiological processes to prevent this activation from happening. Current treatments for autoimmune diseases result in broad immunosuppression, occasionally resulting in infection or insufficient tumor surveillance. We believe the future of treatment for autoimmune disease is specific restoration of self-tolerance rather than immunosuppression, and have established a group in R&D dedicated to this effort.
Big data Every day we generate massive amounts of data in our clinical trials and laboratory experiments that enable us to describe diseases in greater and greater detail. The data includes both how patients and clinicians describe symptoms and response to treatment as well as data that describes the effects a drug has on the body’s molecular and cellular mechanisms. Together this forms a unique knowledge database. With the help of advanced analytics we are able to interrogate this “Big Data” to drive our understanding what targets and pathways may best help resolve disease and what treatment would be best for each patient.
Collaborations
23andMeSince 2014, Pfizer and 23andMe have engaged in an expanding collaboration to help foster research in several different autoimmune and inflammatory diseases including lupus, ulcerative colitis and Crohn’s disease. Our work explores the underlying genetic factors associated with these diseases in the hope of developing new or improved treatments. In addition to enrolling over 15,000 individuals within two separate research initiatives focused on inflammatory bowel disease and lupus, respectively, our most recent partnership gives Pfizer access to 23andMe’s unique research platform and analysis of the company’s genotyped population of over 800,000 individuals who have consented to participate in research. This wealth of patient data offers yet another opportunity to better understand potential links between genetic traits and disease.
BioRapPfizer recently entered into a collaboration, option and license agreement with BioRap Technologies, Ltd., the technology transfer company of the Rappaport Institute of Biomedical Research at the Technion – Israel Institute of Technology. The collaboration is based on work of Dr. Nathan Karim at the Rappaport Institute who has developed a monoclonal antibody that appears to drive the development activity of regulatory T cells – a cell type that plays a role in controlling autoimmunity. This antibody may offer a new potential treatment for certain autoimmune diseases, including inflammatory bowel disease (IBD) and multiple sclerosis (MS).
Work with Us
If you’re interested in collaborating with our Inflammation and Immunology teams, visit our Immunoscience Partnering and Inflammation and Immunology pages to learn more about the work we’re pursuing.
Meet Some of Pfizer’s Inflammation and Immunology Researchers
Michael S. Vincent, MD, PhD
Senior Vice President, Chief Scientific Officer of
Inflammation and Immunology Research and Development
Mike Vincent, MD, PhD, is Senior Vice President and Chief Scientific Officer of the Inflammation and Immunology Research Unit, leading the scientific pipeline for Rheumatology, Gastroenterology and Dermatology specialties through the end of phase 2.
Dr. Vincent earned his BA, PhD, and MD degrees from Indiana University. He completed his residency and began his post-doctoral and rheumatology training at the University of Vermont, completing his fellowship at Brigham and Women’s Hospital. His research while on faculty at Harvard centered on human T cell-dendritic cell interactions, and basic mechanisms of autoimmunity.
Since joining Pfizer in 2011, he has held several scientific leadership roles, most recently as Clinical Head for Pharmatherapeutics in Cambridge, MA. Over this period, he has had responsibility for clinical and translational science in the Inflammation and Immunology, Rare Disease and the Cardiovascular and Metabolic Disease Research Units, and the Centers for Therapeutic Innovation.
Before joining Pfizer, Dr. Vincent held positions of increasing responsibility within Medical Sciences at Amgen, ultimately leading early clinical development for the Immunology and Neuroscience therapeutic areas.
Jot Hui Ooi, PhD
Senior Scientist
Jot Hui Ooi, PhD, is a Postdoctoral Fellow within Pfizer's Inflammation & Immunology Research Unit. She joined Pfizer in 2013 to carry out her postdoctoral research under the mentorship of Nilufer Seth and has recently been promoted to Senior Scientist in Tolerance Group reporting to Aaron Winkler. Her central research interest is to understand the cellular and molecular mechanisms of action underlying immune tolerance induction.
Dr. Ooi received her BS in Biotechnology and Life Sciences from Tokyo University of Agriculture and Technology in Japan and her PhD in Pathobiology with a focus on Immunology from The Pennsylvania State University.
During her postdoctoral training, Dr. Ooi has discovered a novel role of a G-protein Coupled Receptors in promoting host immunity against intestinal inflammation through modulation of innate lymphoid cells and inflammasomes. She is specialized in mucosal immunology, autoimmunity, and gut microbiome, with advanced technical skills in the animal models of inflammation, multicolor fluorescence-activated cell sorting, cell-based assays, and molecular biology techniques.
Selected Publications from the Inflammation and Immunology Research Unit
- Discovery of a novel JAK3-selective inhibitor: Functional differentiation of JAK3-selective inhibition over pan-JAK or JAK1-selective inhibition ACS Chemical Biology Telliez JB, Dowty ME, Wang L, Jussif J, Lin T, Li L, Moy E, Balbo P, Li W, Zhao Y, Crouse K, Dickinson C, Symanowicz P, Hegen M, Banker ME, Vincent F, Unwalla R, Liang S, Gilbert AM, Brown MF, Hayward M, Montgomery J, Yang X, Bauman J, Trujillo JI, Casimiro-Garcia A, Vajdos FF, Leung L, Geoghegan KF, Quazi A, Xuan D, Jones LH, Hett E, Wright K, Clark JD, Thorarensen A. October 28 2016
- Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation The Journal of Immunology Primiano MJ, Lefker BA, Bowman MR, Bree AG, Hubeau C, Bonin PD, Mangan M, Dower K, Monks BG, Cushing L, Wang S, Guzova J, Jiao A, Lin LL, Latz E, Hepworth D, Hall JP. September 15 2016
- Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide Nature, Scientific Reports Liu S, Desharnais J, Sahasrabudhe PPV, Jin P, Li W, Oates B, Shanker S, Banker ME, Chrunyk B, Song X, Feng X, Griffor M, Jimenez J, Chen G, Tumelty D, Bhat A, Bradshaw C, Woodnutt G, Lappe R, Thorarensen A, Qiu X, Withka J, Wood L. May 17 2016
- Oral and inhaled p38 MAPK inhibitors: effects on inhaled LPS challenge in healthy subjects European Journal of Clinical Pharmacology Singh D, Siew L, Christensen J, Plumb J, Clarke GW, Greenaway S, Perros-Huguet C, Clarke N, Kilty I, Tan L. August 13 2015
- Network pharmacology of JAK inhibitors Proceedings of the National Academy of Sciences Moodley D, Yoshida H, Mostafavi S, Asinovski N, Ortiz-Lopez A, Symanowicz P, Telliez JB, Hegen M, Clark JD, Mathis D, Benoist C. June 24 2016
- Parsing the Interferon Transcriptional Network and Its Disease Associations Cell Mostafavi S, Yoshida H, Moodley D, LeBoité H, Rothamel K, Raj T, Ye CJ, Chevrier N, Zhang SY, Feng T, Lee M, Casanova JL, Clark JD, Hegen M, Telliez JB, Hacohen N, De Jager PL, Regev A, Mathis D, Benoist C, Immunological Genome Project Consortium. January 28 2016
- Soluble Fn14 Is Detected and Elevated in Mouse and Human Kidney Disease PLoS One Sharif MN, Campanholle G, Nagiec EE, Wang J, Syed J, O'Neil SP, Zhan Y, Brenneman K, Homer B, Neubert H, Karim R, Pullen N, Evans SM, Fleming M, Chockalingam P, Lin LL. May 12 2016
